The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth
The correlation of pore morphology, interconnectivity and physical properties of 3D ceramic scaffolds with bone ingrowth
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DOI：
10.1016/j.biomaterials.2008.10.056
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发表时间：
2009-03-01
期刊：
影响因子：
14
通讯作者：
Knackstedt, Mark A.
中科院分区：
文献类型：
--
作者：
Jones, Anthony C.;Arns, Christoph H.;Knackstedt, Mark A.
在组织工程支架的设计中，应优化设计参数，包括孔径、形状和互连性、机械性能和运输性能，以最大限度地成功诱导骨长入。在本文中，我们描述了一个3D微CT和孔隙分区研究，以获得孔隙尺度参数，包括孔隙半径分布，可达半径，喉半径，和连通性的组织工程结构的孔隙空间。这些孔隙尺度描述符与骨长入支架相关。定量和目视比较显示，局部可及孔隙半径和骨长入之间有很强的相关性;对于连接良好的样本，观察到长入的截止可及孔隙半径类似于100 μ M。模拟不同类型支架的弹性性质，并且可以通过标准细胞固体理论来描述：（E/E-0）-（rho/rho（s））（n）。水力传导和扩散性能的计算结果是一致的概念的阈值传导骨长入。局部流速和局部剪切应力的简单模拟显示与体内骨长入模式无关。这些结果表明，三维成像和分析的潜力，以定义相关的孔隙尺度的形态和物理性能的支架内，并提供证据的孔隙尺度的描述符，物理性能和骨长入之间的相关性。皇冠版权所有（c）2008由爱思唯尔有限公司出版。保留所有权利。
In the design of tissue engineering scaffolds, design parameters including pore size, shape and interconnectivity, mechanical properties and transport properties should be optimized to maximize successful inducement of bone ingrowth. In this paper we describe a 3D micro-CT and pore partitioning study to derive pore scale parameters including pore radius distribution, accessible radius, throat radius, and connectivity over the pore space of the tissue engineered constructs. These pore scale descriptors are correlated to bone ingrowth into the scaffolds. Quantitative and visual comparisons show a strong correlation between the local accessible pore radius and bone ingrowth; for well connected samples a cutoff accessible pore radius of similar to 100 mu M is observed for ingrowth. The elastic properties of different types of scaffolds are simulated and can be described by standard cellular solids theory: (E/E-0)-(rho/rho(s))(n). Hydraulic conductance and diffusive properties are calculated; results are consistent with the concept of a threshold conductance for bone ingrowth. Simple simulations of local flow velocity and local shear stress show no correlation to in vivo bone ingrowth patterns. These results demonstrate a potential for 3D imaging and analysis to define relevant pore scale morphological and physical properties within scaffolds and to provide evidence for correlations between pore scale descriptors, physical properties and bone ingrowth. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved.