ABC transporter research: going strong 40 years on.
ABC transporter research: going strong 40 years on.
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DOI：
10.1042/bst20150139
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发表时间：
2015-10
影响因子：
3.9
通讯作者：
Kerr ID
中科院分区：
文献类型：
--
作者：
Theodoulou FL;Kerr ID
在大多数生物体中，ABC转运蛋白是最大的膜蛋白家族之一。在人类中，它们的功能是多样的，是许多关键的生理过程的基础，也是许多临床相关病理的致病因素。我们对这些疾病的理解是通过结合对这些转运蛋白的遗传和蛋白质生化研究而取得的，体外和体内研究的力量有助于发展对基因-表型的理解。然而，ABC转运蛋白研究的重要性远远超出了人类生物学；微生物ABC转运蛋白在了解毒力和耐药性方面具有极大的兴趣，工业生物技术研究人员正在探索原核生物ABC转运蛋白在提高合成生物学系统能力方面的潜力。植物ABC转运蛋白在激素、外源物质、金属和次生代谢物的运输、病原菌的响应和发育的诸多方面发挥着重要作用，所有这些都在全球粮食安全领域发挥着重要作用。在切斯特为期3天的时间里，这场生化学会聚焦的会议将具有不同实验方法和不同基本问题的研究人员聚集在一起，所有这些都通过ABC转运蛋白的共性联系在一起。
In most organisms, ABC transporters constitute one of the largest families of membrane proteins. In humans, their functions are diverse and underpin numerous key physiological processes, as well as being causative factors in a number of clinically relevant pathologies. Advances in our understanding of these diseases have come about through combinations of genetic and protein biochemical investigations of these transporters and the power of in vitro and in vivo investigations is helping to develop genotype–phenotype understanding. However, the importance of ABC transporter research goes far beyond human biology; microbial ABC transporters are of great interest in terms of understanding virulence and drug resistance and industrial biotechnology researchers are exploring the potential of prokaryotic ABC exporters to increase the capacity of synthetic biology systems. Plant ABC transporters play important roles in transport of hormones, xenobiotics, metals and secondary metabolites, pathogen responses and numerous aspects of development, all of which are important in the global food security area. For 3 days in Chester, this Biochemical Society Focused Meeting brought together researchers with diverse experimental approaches and with different fundamental questions, all of which are linked by the commonality of ABC transporters.