Carnosine-induced antidepressant-like activity in rats
Carnosine-induced antidepressant-like activity in rats
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DOI：
10.1016/j.pbb.2008.02.021
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发表时间：
2008-06-01
影响因子：
3.6
通讯作者：
Furuse, Mitsuhiro
中科院分区：
文献类型：
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作者：
Tomonaga, Shozo;Yamane, Haruka;Furuse, Mitsuhiro
抑郁症是一种病态的情绪状态，被认为是残疾的主要原因之一。因此，预防抑郁症和照顾抑郁症患者是很重要的。在本研究中，我们研究了单次口服CBEX（鸡胸提取物）或肌肽（CBEX的主要成分之一）是否会影响雄性Wistar大鼠在强迫游泳试验中的不动时间，这是抑郁样行为的指标。CBEX倾向于（P=0.09），肌肽显著（P
Depression is a pathological state of mood and is considered as one of the major causes of disabilities. Thus, the prevention of depression and care for individuals with depression is important. In the present study, we examined whether a single oral dose of CBEX (chicken breast extract), or carnosine (one of the major components of CBEX) affects immobility time, an index of depressive-like behavior, in the forced swimming test in male Wistar rats. CBEX tended to (P=0.09) and carnosine significantly (P