Association between Hemoglobin and Hemoglobin A1c: A Data-Driven Analysis of Health Checkup Data in Japan
Association between Hemoglobin and Hemoglobin A1c: A Data-Driven Analysis of Health Checkup Data in Japan
复制标题
DOI：
10.3390/jcm7120539
复制
发表时间：
2018-12-01
影响因子：
3.9
通讯作者：
Kawakami, Koji
中科院分区：
文献类型：
--
作者：
Takeuchi, Masato;Kawakami, Koji
背景资料：血红蛋白A（1c）（HbA（1c））水平的解释可能会被贫血患者的假结果所混淆，但其程度尚不明确。研究方法：我们使用了一个基于雇主的健康保险数据库，其中包含健康检查数据和医疗索赔数据;两者都通过每个受益人的唯一标识符链接。这项研究包括年龄在18-75岁之间的人，他们参加了健康检查，确诊或怀疑患有糖尿病。血红蛋白（Hb）和HbA（1c）之间的关系使用机器学习技术在样条曲线中显示，考虑到患者因素和人内相关性。样条曲线也显示在几个亚群体。结果：总体而言，Hb值降低与HbA（1c）值降低相关，但不同人群之间的程度不同。在2型糖尿病组的整个队列（55，420人）中，具有Hb值的人的曲线通常是平台
Background: Interpretation of hemoglobin A(1c) (HbA(1c)) levels may be confounded by spurious results in anemic persons, but its degree is not well-established. Methods: We used an employer-based health insurance database, containing health checkup data and medical claims data; both were linked via a unique identifier of each beneficiary. This study included persons aged 18-75 years who participated in health checkups, with a confirmed or suspected diagnosis of diabetes. The relationship between hemoglobin (Hb) and HbA(1c) is shown in a spline curve using a machine learning technique accounting for patient factors and within-person correlations. Spline curves were also shown in several sub-populations. Results: Overall, a decreased Hb value was associated with a lower HbA(1c) value, but the extent differed among populations. In the whole cohort of the type-2 diabetes group (55,420 persons), the curve was generally a plateau in the persons with a Hb value