Living-donor liver transplantation in Kyoto, 1997.
Living-donor liver transplantation in Kyoto, 1997.
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1997 年在京都进行活体肝移植。
DOI：
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发表时间：
1997
期刊：
影响因子：
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通讯作者：
Koichi Tanaka
中科院分区：
文献类型：
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作者：
T. Kiuchi;Y. Inomata;S. Uemoto;K. Asonuma;H. Egawa;M. Hayashi;S. Fujita;Koichi Tanaka
尽管最近一项允许从脑死亡捐赠者身上提取器官的新法律生效，但活体捐赠者仍然是日本肝脏移植的主要来源。京都大学的LDLT病例数逐年增加，1997年11月达到329例患者中的336例移植。由于该计划在没有尸体器官来源支持的情况下扩大，我们面临着移植物尺寸不匹配，主要ABO血型不相容和高度恶化的急诊病例的困难。尽管手术技术的创新减少了血管并发症，并采用了几种免疫调节来减轻血型不匹配的并发症，但这些病例的移植物存活率仍比不太复杂的移植物低约20%。本报告总结了我们最近与这些问题的斗争以及我们的一些解决方案。
Although a new law allowing for organ retrieval from brain-dead donors was recently put into force, living donors remain the major source for liver transplantation in Japan. The number of LDLT cases in Kyoto University has increased yearly, reaching 336 transplantations in 329 patients in November 1997. Because the program has expanded without support from cadaveric organ sources, we have been confronted with difficulties with graft size mismatches, major ABO blood group incompatibilities and highly deteriorated emergency cases. Despite innovations in surgical techniques which have reduced vascular complications, and several immunomodulations to mitigate complications of mismatched blood groups, graft survival in these cases remains approximately 20% lower than that for less complicated transplants. This report summarizes our recent struggles with these problems and some of our solutions.