The Importance of Human Tissue Bioresources in Advancing Biomedical Research
The Importance of Human Tissue Bioresources in Advancing Biomedical Research
复制标题
DOI：
10.1089/bio.2019.0039
复制
发表时间：
2019-06-01
影响因子：
1.6
通讯作者：
Grizzle, William E.
中科院分区：
文献类型：
--
作者：
Al Diffalha, Sameer;Sexton, Katherine C.;Grizzle, William E.
医学研究的进步使得精准医学的实现在很大程度上依赖于生物资源提供的生物标本来确定靶点和生物标志物，这些靶点和生物标志物是新一代更有效的针对特定亚型疾病的基于分子的治疗的重点。通过他们分发的生物标本，生物资源使癌症亚型得以识别，这些亚型的分子特征得以有效靶向。一个典型的例子是人表皮生长因子受体2型（HER2），它目前是乳腺癌和胃癌的靶点。在未来，对生物资源中生物标本的使用将继续增加对药物分子作用的理解，以及药物如何在患者亚群中或多或少地发挥作用。虽然最初形式的生物资源的生物标本清单可能并不总是得到最佳规划，因此无法用于支持生物医学研究，但生物资源正在不断发展，总体而言，生物资源清单及其预期的收集能力将继续成为研究基础设施的关键组成部分。
Medical research advances enabling the realization of precision medicine have relied heavily on the biospecimens provided by bioresources to identify the targets and biomarkers that are the focus of the new generation of more effective molecular-based therapies for specific subtypes of diseases. Through the biospecimens they have distributed, bioresources have permitted subtypes of cancers to be identified and molecular features of these subtypes to be effectively targeted. A prototype example is the human epidermal growth factor receptor type 2 (HER2), which currently is targeted in breast and gastric cancers. In the future, the use of biospecimens from bioresources will continue to increase the understanding of the molecular actions of drugs and how drugs may be more or less active in subpopulations of patients. Although the biospecimen inventories of the initial forms of bioresources may not have always been optimally planned and, therefore, utilized in supporting biomedical research, bioresources are evolving and overall, bioresource inventories and increasingly their prospective collection capabilities will continue to be a critical component of the research infrastructure.