Homoarginine Levels Are Regulated by L-Arginine: Glycine Amidinotransferase and Affect Stroke Outcome Results From Human and Murine Studies
Homoarginine Levels Are Regulated by L-Arginine: Glycine Amidinotransferase and Affect Stroke Outcome Results From Human and Murine Studies
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DOI：
10.1161/circulationaha.112.000580
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发表时间：
2013-09-24
期刊：
影响因子：
37.8
通讯作者：
Schwedhelm, Edzard
中科院分区：
文献类型：
--
作者：
Choe, Chi-un;Atzler, Dorothee;Schwedhelm, Edzard
背景 内源性精氨酸同系物，包括高精氨酸，已被确定为心血管疾病和结果的新型生物标志物。我们对人类队列和验证性小鼠模型的研究将精氨酸同源物高精氨酸及其代谢与中风病理学和结果相关联。方法和结果增加高精氨酸水平与缺血性中风患者全因死亡率的降低独立相关（随访 7.4 年；1-SD 高精氨酸的风险比，0.79 [95% 置信区间，0.64-0.96]； P=0.019；n=389)。高精氨酸还与美国国立卫生研究院卒中量表+年龄评分以及缺血性卒中后 30 天死亡率独立相关（P
Background Endogenous arginine homologues, including homoarginine, have been identified as novel biomarkers for cardiovascular disease and outcomes. Our studies of human cohorts and a confirmatory murine model associated the arginine homologue homoarginine and its metabolism with stroke pathology and outcome.Methods and Results Increasing homoarginine levels were independently associated with a reduction in all-cause mortality in patients with ischemic stroke (7.4 years of follow-up; hazard ratio for 1-SD homoarginine, 0.79 [95% confidence interval, 0.64-0.96]; P=0.019; n=389). Homoarginine was also independently associated with the National Institutes of Health Stroke Scale+age score and 30-day mortality after ischemic stroke (P