Contribution of electron microscopy to the classification of minimally differentiated acute leukemias in children.
Contribution of electron microscopy to the classification of minimally differentiated acute leukemias in children.
复制标题
电子显微镜对儿童微分化急性白血病分类的贡献。
DOI：
10.1007/978-3-642-84895-7_8
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
J. V. van Dongen
中科院分区：
文献类型：
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作者：
E. V. van Wering;P. Brederoo;G. J. van Staalduinen;J. Van der Meulen;B. E. van der Linden;J. V. van Dongen
In recent multiparameter studies, ultrastructural morphology and cytochemistry of undifferentiated or minimally differentiated acute leukemia’s have been investigated (Lee et al. 1987; Matutes et al. 1988; Campana et al. 1990; Van Wering et al. 1990; Heil et al. 1991). Detection of myeloperoxidase (MPO) and platelet peroxidase (PPO) at the ultrastructural level appeared to be useful for myeloid leukemia’s (Bennett et al. 1991) and supportive for the diagnosis of megakaryocytic leukemias (Breton-Gorius et al. 1978; Bennett et al. 1985). We investigated 12 light-microscopically unclassifiable acute childhood leukemia’s by immunological marker analysis and by electron microscopy (EM), including peroxidase cytochemistry. The combined results appeared to provide information to diagnose conclusively cases of minimally differentiated acute myeloid leukemia’s (AML M0; Bennett et al. 1991) and acute megakaryoblastic leukemia (AML M7; Bennett et al. 1985).
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