The association between chronic periodontitis and vasculogenic erectile dysfunction: a systematic review and meta-analysis
The association between chronic periodontitis and vasculogenic erectile dysfunction: a systematic review and meta-analysis
复制标题
慢性牙周炎与血管源性勃起功能障碍之间的关联：系统评价和荟萃分析
DOI：
10.1111/jcpe.12512
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发表时间：
2016
影响因子：
6.7
通讯作者：
Zhao Lei
中科院分区：
文献类型：
--
作者：
Wang Qianting;Kang Jian;Cai Xiang;Wu Yafei;Zhao Lei
AimThe purpose of this systematic review and meta‐analysis was to explore the association between erectile dysfunction (ED) and chronic periodontitis (CP) in observational studies.Materials and MethodsA literature search of PubMed, EMBASE and Cochrane up to and including May 22, 2015, was conducted by two independent reviewers. Statistical analysis was performed using Review Manager 5.3, and the results are expressed as odds ratios (ORs) together with 95% confidence intervals (CIs), as determined using a random effects model. Subgroup analysis was performed by age.ResultsOf the 250 potentially eligible articles, four studies, involving 38,111 cases and 174,807 controls, were included. Based on random effects meta‐analysis, a significant association between CP and ED was identified (OR = 3.07, 95% CI: 1.87–5.05,p< 0.001). Sensitivity analysis was performed due to the presence of statistically extensive heterogeneity (I2= 98%).ConclusionsThe results of this systematic review revealed a positive association between CP and ED; however, because the presence and extent of statistical heterogeneity limits the conclusiveness of our findings, larger and better‐controlled studies of socially homogeneous populations as well as pathophysiological studies are required to confirm the relationship between CP and ED and to explore the biological mechanisms involved.
