Probiotics and immune response
Probiotics and immune response
复制标题
DOI：
10.1016/s0002-9270(99)00813-8
复制
发表时间：
2000-01-01
影响因子：
9.8
通讯作者：
Cervia, J
中科院分区：
文献类型：
--
作者：
Cunningham-Rundles, S;Ahrné, S;Cervia, J
目前的证据支持这样的概念，即口服益生菌乳酸杆菌可能有助于预防儿童抗生素相关性腹泻和重建胃肠道正常菌群。感染人类免疫缺陷病毒（HIV）的儿童可能会出现腹泻，并经常出现与可能的细菌过度生长相关的吸收不良；这些因素共同作用可能会产生该群体特有的生长异常。本研究的总体目标是确定口服益生菌植物乳杆菌 299v 是否可以改善先天接触 HN 的儿童的营养状况并促进生长。此外，还评估了植物乳杆菌 299v 在调节免疫反应方面可能的有益作用。在此描述的初步结果中，我们报告了植物乳杆菌 299v 在口服补充剂后定植艾滋病毒儿童并引发特异性全身免疫反应的能力。
Current evidence supports the concept that oral administration of probiotic lactobacilli may be therapeutic in preventing antibiotic-associated diarrhea in children and in reestablishing normal flora in the gastrointestinal tract. Children with human immunodeficiency virus (HIV) infections may have episodes of diarrhea and frequently experience malabsorption associated with possible bacterial overgrowth; together these may interact to produce the growth abnormalities characteristic of this group. The overall objective of this investigation has been to determine whether oral administration of the probiotic Lactobacillus plantarum 299v could improve nutrient status and promote growth in children congenitally exposed to HN. In addition, the possible beneficial effect of Lactobacillus plantarum 299v in modulating immune response was evaluated. In preliminary results described here, we report on the ability of Lactobacillus plantarum 299v to colonize children with HIV and to elicit specific systemic immune response after oral supplementation.