Layered evolution in the immune system: a view from history.
Layered evolution in the immune system: a view from history.
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DOI：
10.1111/nyas.12795
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发表时间：
2015-12
影响因子：
5.2
通讯作者：
Herzenberg LA
中科院分区：
文献类型：
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作者：
Herzenberg LA
虽然还有很多东西有待研究，但在1991年第一次大型B-1a会议召开时，表明B-1a淋巴细胞很可能属于一个独特谱系的证据已基本到位。参加那次会议的免疫学家（包括本城佑子和克劳斯·拉科夫斯基）开发并最终发表了B-1a标记法，至今仍在使用。在这里，我简要回顾了一些早期的B-1a的研究结果，目前的研究基础。最后，我简要总结了最近的研究，主要是从我的实验室，表明造血干细胞（HSC），我们都知道和爱作为细胞的起源，填充成人淋巴和骨髓系统的今天，但不是起源的B-1a淋巴细胞，我们大多数人今天的工作。
Although much had still to be learned, evidence indicating that B-1a lymphocytes very likely belonged to a distinct lineage was largely in place by the time of the first large B-1a conference in 1991. The widely respected group of immunologists attending that meeting (including Tasuko Honjo and Klaus Rajewsky) developed and ultimately published the B-1a notation still in use today. Here, I briefly review some of the early B-1a findings that underlie current studies. I close with a brief summary of recent studies, mainly from my laboratory, showing that the hematopoietic stem cell (HSC) we all know and love as the origin of the cells that populate the adult lymphoid and myeloid system today is nonetheless not the origin of the B-1a lymphocytes with which most of us work today.