Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine.
Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine.
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DOI：
10.1039/c4ob01844c
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发表时间：
2015-01
影响因子：
3.2
通讯作者：
Haipin Zhou;Kuo Gai;Aijun Lin;Jinyi Xu;Xiao-ming Wu;Hequan Yao
中科院分区：
文献类型：
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作者：
Haipin Zhou;Kuo Gai;Aijun Lin;Jinyi Xu;Xiao-ming Wu;Hequan Yao
本发明公开了一种在温和条件下通过钯催化的C-H双键断裂来制备5-（3-吲哚基）唑的有效和直接的方法，所述5-（3-吲哚基）唑包含吲哚和唑的特权结构。正如预期的那样，该方案提供了一个简单的方法，以中等产率合成吲哚生物碱pimprinine和WS-30581 A。
An efficient and straightforward method for the production of 5-(3-indolyl)azoles incorporating the privileged structures indoles and azoles via palladium-catalyzed double C-H bond cleavage under mild conditions was disclosed. As expected, this protocol provided an easy method for the synthesis of indole alkaloids pimprinine and WS-30581 A in moderate yields.