Oxytocin changes behavior and spatio-temporal brain dynamics underlying inter-group conflict in humans
Oxytocin changes behavior and spatio-temporal brain dynamics underlying inter-group conflict in humans
复制标题
DOI：
10.1016/j.euroneuro.2019.12.109
复制
发表时间：
2019-12
影响因子：
5.6
通讯作者：
Bastian Schiller;G. Domes;M. Heinrichs
中科院分区：
文献类型：
--
作者：
Bastian Schiller;G. Domes;M. Heinrichs
群体间冲突导致了人类歧视、大规模移民和暴力，但其心理生物学机制在很大程度上仍不为人所知。在这里，我们调查是否神经肽催产素调制行为和时空的大脑动力学在自然的组间冲突。86名自然竞争对手社会群体的男性成员鼻内接受催产素或安慰剂。在一个涉及真实的货币风险的决策范式中，参与者可以牺牲自己的资源来调节组内和组外成员的货币收益和损失。催产素消除了外群体收益的减少-特别是在情绪同情心低的个体中，而那些服用安慰剂的人表现出这种负面的社会行为。我们的时空分析结果评价引起的事件相关电位显示，催产素取代了与负评价的外群体收益的神经生理过程，通过与积极评价结果呈现后200- 500毫秒之间的过程。因此，催产素似乎通过一种与评价相关的大脑动力学的特定改变来调节人类的群体间行为。
Inter-group conflicts drive human discrimination, mass migration, and violence, but their psychobiological mechanisms remain largely unknown. Here, we investigated whether the neuropeptide oxytocin modulates behavior and spatio-temporal brain dynamics in naturalistic inter-group conflict. Eighty-six male members of natural rival social groups received either oxytocin or placebo intranasally. In a decision-making paradigm involving real monetary stakes, participants could sacrifice their own resources to modulate the monetary gains and losses of in- and out-group members. Oxytocin eliminated the reduction in out-group gains – particularly in individuals with low emotional empathy, whereas those given placebo exhibited this negative social behavior. Our spatio-temporal analysis of event-related potentials elicited by outcome valuation revealed that oxytocin replaced a neurophysiological process associated with the negative valuation of out-group gains via a process associated with positive valuation between 200-500ms after outcome presentation. Oxytocin thus seems to modulate inter-group behavior in humans via a specific alteration of valuation-related brain dynamics.