The impact of radiotherapy on quality of life for cancer patients: a longitudinal study
The impact of radiotherapy on quality of life for cancer patients: a longitudinal study
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放射治疗对癌症患者生活质量的影响：一项纵向研究
DOI：
10.1007/s00520-014-2235-y
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发表时间：
2014
影响因子：
3.1
通讯作者：
S. Kılıçkap
中科院分区：
文献类型：
--
作者：
B. Yucel;E. Akkaş;Yıllar Okur;A. Eren;M. Eren;Hanife Karapınar;N. Babacan;S. Kılıçkap
目的本研究的目的是评估接受放射治疗的癌症患者生活质量（QOL）的变化，并确定影响该组患者生活质量的因素。材料与方法采用EORTC QLQ-C30问卷调查367例接受根治性放射治疗的癌症患者，分别在放射治疗开始、结束及放射治疗后1个月和6个月。结果患者女性占49%，男性占51%，诊断时中位年龄为57岁（范围16-86岁）。与放疗前相比，在放疗结束时，总体健康状态评分（p< 0.001）、恶心/呕吐（p< 0.001）和食欲下降评分（p< 0.001）明显较差。与放疗结束时相比，在放疗后1个月和6个月，总体健康状况、所有功能和所有症状评分均显著改善（p< 0.001）。患者性别影响疼痛评分（p= 0.036）、食欲减退评分（p= 0.027）和经济困难评分（p= 0.003）。表现状态影响整体健康状态（p= 0.006）、身体功能（p< 0.001）、认知功能（p= 0.001）和角色功能（p= 0.021）的得分。合并症影响疲劳评分（p< 0.001）。癌症分期影响身体功能（p= 0.001）、角色功能（p= 0.010）和疲劳（p< 0.001）的评分。治疗方式（化疗ort vs单纯放疗）影响身体功能评分（p= 0.016）、疲劳（p< 0.001）、恶心/呕吐（p= 0.009）和食欲减退（p< 0.001）；RT场影响恶心/呕吐（p= 0.001）、食欲减退（p= 0.003）和腹泻（p= 0.037）的评分。放疗剂量功能（p< 0.001）、认知功能（p< 0.001）、社会功能（p< 0.001）、疲劳（p< 0.001）和疼痛（<60 Gy vs≥60 Gy）对身体功能（p< 0.001）、角色功能（p< 0.001）、情绪（p< 0.001）、失眠（p< 0.001）、便秘（p< 0.001）评分有影响。结论放疗虽对肿瘤患者的生活质量有负面影响，但术后1个月患者的生活质量恢复较快，有明显改善。各种患者和疾病特异性因素和RT方式影响该患者组的生活质量。我们提倡定期测量癌症患者的生活质量，作为患者日常管理的一部分。
PurposeThe aim of this study was to assess for changes in quality of life (QOL) among cancer patients who undergo radiotherapy (RT) and to identify factors that influence QOL in this group.Materials and methodsThree hundred sixty-seven cancer patients who received curative RT were investigated using the EORTC QLQ-C30 questionnaire at the start of RT, end of RT, and 1 and 6 months post-RT.ResultsThe patients were 49 % women, 51 % men, and median age at diagnosis was 57 years (range, 16–86 years). Compared to pre-RT, at the end of RT, the global health status score (p< 0.001), nausea/vomiting (p< 0.001), and apetite loss scores (p< 0.001) were significantly poorer. Compared to the end of RT, at 1 and 6 months post-RT, global health status, all functional, and all symptom scores were significantly improved (p< 0.001). Patient sex influenced scores for pain (p= 0.036), appetite loss (p= 0.027), and financial difficulty (p= 0.003). Performance status influenced scores for global health status (p= 0.006), physical functioning (p< 0.001), cognitive functioning (p= 0.001), and role functioning (p= 0.021). Comorbidity influenced fatigue score (p< 0.001). Cancer stage influenced scores for physical functioning (p= 0.001), role functioning (p= 0.010), and fatigue (p< 0.001). Treatment modality (chemoRT vs. RT alone) influenced scores for physical functioning (p= 0.016), fatigue (p< 0.001), nausea/vomiting (p= 0.009), and appetite loss (p< 0.001); and RT field influenced scores for nausea/vomiting (p= 0.001), appetite loss (p= 0.003), and diarrhea (p= 0.037). Radiotherapy dose functioning (p< 0.001), cognitive functioning (p< 0.001), social functioning (p< 0.001), fatigue (p< 0.001), and pain (<60 vs ≥60 Gy) had an effect on scores for physical functioning (p< 0.001), role functioning (p< 0.001), emotional (p< 0.001), insomnia (p< 0.001), constipation (p< 0.001).ConclusionWhile RT negatively affects cancer patients’ QOL, restoration tends to be rapid and patients report significant improvement by 1 month post-RT. Various patient- and disease-specific factors and RT modality affect QOL in this patient group. We advocate measuring cancer patients’ QOL regularly as part of routine patient management.
接受剂量密集化疗的患者的生活质量、食欲和体重变化。
DOI：
--
发表时间：
1994
期刊：
Oncology. 8
影响因子：
--
作者：
Takata S;Hashimoto J;Nakatsuka K;Yoshimura N;Yoh K;Ohno I;et al.;Yoshiko Dohi;Osoba D et al.
通讯作者：
Osoba D et al.
医学研究与患者的“个人权利”
DOI：
--
发表时间：
2007
期刊：
The Journal of Social Science Vol.58, No.2
影响因子：
--
作者：
NAKAMASA;Masaki
通讯作者：
Masaki