Digital tomosynthesis with an on-board kilovoltage imaging device
Digital tomosynthesis with an on-board kilovoltage imaging device
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DOI：
10.1016/j.ijrobp.2006.01.025
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发表时间：
2006-05-01
影响因子：
7
通讯作者：
Willett, C
中科院分区：
文献类型：
--
作者：
Godfrey, DJ;Yin, FF;Willett, C
目的：为了生成板上的数字断层合成（TOMO）和参考TOMO图像的三维图像引导放射治疗（IGRT）作为替代传统的门静脉成像或板上的锥形束计算机断层扫描（CBCT）。方法和材料：三个临床病例（前列腺，头颈部和肝脏）被选中，以说明板上的TOMO IGRT的能力。根据计划CT图像集计算的数字重建X线片重建相应的参考CT图像。通过计算CBCT和CT图像之间的互信息，研究了扫描角度对CT层厚的影响，当CT扫描角度从0 °变化到165 °时。实施屏气CT采集策略，以消除呼吸运动artifacts.Results：数字断层合成切片出现类似于一致的CBCT平面，并产生了更多的解剖信息比千伏或兆伏射线照片。屏气采集通过抑制呼吸motion.Conclusions改善软组织的可见性：改善骨和软组织的可见性在MRI图像可能会提高目标定位相比，放射学验证技术，并可能允许日常定位的软组织目标。对于易于发生呼吸运动的部位，屏气CT是机载CBCT的潜在替代方案。(c)2006年爱思唯尔公司
Purpose: To generate on-board digital tomosynthesis (DTS) and reference DTS images for three-dimensional image-guided radiation therapy (IGRT) as an alternative to conventional portal imaging or on-board cone-beam computed tomography (CBCT).Methods and Materials: Three clinical cases (prostate, head-and-neck, and liver) were selected to illustrate the capabilities of on-board DTS for IGRT. Corresponding reference DTS images were reconstructed from digitally reconstructed radiographs computed from planning CT image sets. The effect of scan angle on DTS slice thickness was examined by computing the mutual information between coincident CBCT and DTS images, as the DTS scan angle was varied from 0 degrees to 165 degrees. A breath-hold DTS acquisition strategy was implemented to remove respiratory motion artifacts.Results: Digital tomosynthesis slices appeared similar to coincident CBCT planes and yielded substantially more anatomic information than either kilovoltage or megavoltage radiographs. Breath-hold DTS acquisition improved soft-tissue visibility by suppressing respiratory motion.Conclusions: Improved bony and soft-tissue visibility in DTS images is likely to improve target localization compared with radiographic verification techniques and might allow for daily localization of a soft-tissue target. Breath-hold DTS is a potential alternative to on-board CBCT for sites prone to respiratory motion. (c) 2006 Elsevier Inc.