EVIDENCE THAT IRON STORES REGULATE IRON-ABSORPTION - A SETPOINT THEORY
EVIDENCE THAT IRON STORES REGULATE IRON-ABSORPTION - A SETPOINT THEORY
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DOI：
10.1093/ajcn/59.6.1376
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发表时间：
1994-06-01
影响因子：
7.1
通讯作者：
GARRY, PJ
中科院分区：
文献类型：
--
作者：
GAVIN, MW;MCCARTHY, DM;GARRY, PJ
为了评估铁储存的预定“设定值”的概念，研究了20名健康老年人（12名献血者和8名非献血者），以检查铁储存变化对铁吸收的影响。口服铁吸收试验显示，供者的铁吸收量有统计学意义的增加（P < 0.001）， 7.4 +/- 3.6% ((x)超过bar +/- SD)，而非供者的铁吸收量为2.5 +/- 1.4%。在铁吸收量百分比与基线铁储量变化的比较中，发现具有统计学意义的相关性（r(2) = 0.702, P < 0.001）。因此，铁储量的减少与铁吸收的增加有关。所有老年受试者的基础胃酸排泄量均在正常范围内（1.62-10.20 mmol/h），与铁储量无关。这些发现与铁的吸收是根据捐献前铁储量的消耗程度来调节的，这与铁储量的设定值理论是一致的。
To evaluate the concept of a predetermined ''setpoint'' for iron stores, 20 healthy elderly individuals (12 blood donors and 8 nondonors) were studied to examine the effects of changes in iron stores on iron absorption. Oral iron-absorption tests revealed a statistically significant increase (P < 0.001) in iron absorption in donors, 7.4 +/- 3.6% ((x) over bar +/- SD) compared with 2.5 +/- 1.4% in nondonors. In a comparison of percent iron absorption with changes in baseline iron stores, a statistically significant correlation was noted (r(2) = 0.702, P < 0.001). Thus, reductions in iron stores were correlated with increases in iron absorption. Basal gastric acid output was found to be within normal limits (1.62-10.20 mmol/h) in all elderly subjects and unrelated to iron stores. These findings are consistent with iron absorption being regulated according to the degree of depletion of iron stores from predonation values and is consistent with a proposed setpoint theory of iron stores.