Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy
Multivariate analysis of regional metabolic differences in normal ageing on localised quantitative proton MR spectroscopy
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DOI：
10.1007/s002340000513
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发表时间：
2001-06-01
期刊：
影响因子：
2.8
通讯作者：
Uno, M
中科院分区：
文献类型：
--
作者：
Harada, M;Miyoshi, H;Uno, M
我们进行了多变量分析的区域差异和正常的年龄相关的变化，在豆状核和额叶的代谢物，质子MRS测量。在测量区域的脑脊液（CSF）进行了估计和代谢物浓度调整。豆状核的N-乙酰天门冬氨酸（NAA）含量随增龄而降低（F = 4.11，P < 0.01），额叶的NAA含量无明显变化（F = 0.93，P = 0.45）。这与病理性痴呆形成鲜明对比，如阿尔茨海默病。在这个多变量分析中，正常的代谢变化与年龄不同的大脑区域，这表明代谢物的浓度，特别是NAA的可能是有用的代谢指标，用于区分正常老化的病理性痴呆。
We performed multivariate analysis of regional differences and normal age-related changes in metabolites in the lentiform nucleus and frontal lobe, as measured by proton MRS. The cerebrospinal fluid (CSF) in the measurement area was estimated and the metabolite concentration adjusted. The concentration of N-acetylaspartate (NAA) in the lentiform nucleus decreased with ageing (F = 4.11, P < 0.01), but that in the frontal lobe did not change (F = 0.93, P = 0.45). This is in marked contrast with pathological dementia, such as Alzheimer's disease. In this multivariate analysis, the normal change in metabolism with ageing differed depending on the cerebral region, suggesting that metabolite concentrations, especially that of NAA may be useful metabolic indices for discriminate normal ageing from pathological dementia.