OBESITY AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR-DISEASE - A 26-YEAR FOLLOW-UP OF PARTICIPANTS IN THE FRAMINGHAM HEART-STUDY
OBESITY AS AN INDEPENDENT RISK FACTOR FOR CARDIOVASCULAR-DISEASE - A 26-YEAR FOLLOW-UP OF PARTICIPANTS IN THE FRAMINGHAM HEART-STUDY
复制标题
DOI：
10.1161/01.cir.67.5.968
复制
发表时间：
1983-01-01
期刊：
影响因子：
37.8
通讯作者：
CASTELLI, WP
中科院分区：
文献类型：
--
作者：
HUBERT, HB;FEINLEIB, M;CASTELLI, WP
在最初的 Framingham 队列中的 5209 名男性和女性中重新检查了肥胖程度与心血管疾病 (CVD) 发病率之间的关系。最近对 26 年来疾病发生情况的观察表明，通过都市相对体重衡量的肥胖是 CVD 的一个重要的独立预测因素，特别是在女性中。多元逻辑回归分析表明，初次检查时的都市相对体重或理想体重百分比可预测男性 26 年冠心病（心绞痛和心绞痛以外的冠心病）、冠心病死亡和充血性心力衰竭的发病率，与年龄、胆固醇、收缩压、吸烟、左心室肥大和葡萄糖耐受不良无关。女性的相对体重也与冠心病、中风、充血性衰竭以及冠心病和心血管疾病死亡呈正相关且独立相关。成年后的体重增加表明男女患 CVD 的风险均增加，这既不能归因于初始体重，也不能归因于体重增加可能导致的危险因素水平。除了已确定的危险因素之外，对肥胖的干预似乎是心血管疾病一级预防的一个可取目标。
The relationship between the degree of obesity and the incidence of cardiovascular disease (CVD) was reexamined in the 5209 men and women of the original Framingham cohort. Recent observations of disease occurrence over 26 yr indicate that obesity, measured by Metropolitan Relative Weight, was a significant independent predictor of CVD, particularly among women. Multiple logistic regression analyses showed that Metropolitan Relative Weight, or percentage of desirable weight, on initial examination predicted 26-yr incidence of coronary disease (both angina and coronary disease other than angina), coronary death and congestive heart failure in men independent of age, cholesterol, systolic blood pressure, cigarettes, left ventricular hypertrophy and glucose intolerance. Relative weight in women was also positively and independently associated with coronary disease, stroke, congestive failure and coronary and CVD death. Weight gain after the young adult yr conveyed an increased risk of CVD in both sexes that could not be attributed either to the initial weight or the levels of the risk factors that may have resulted from weight gain. Intervention in obesity, in addition to the well established risk factors, appears to be an advisable goal in the primary prevention of CVD.