REPAIR OF BONE DEFECTS WITH MARROW-CELLS AND POROUS CERAMIC - EXPERIMENTS IN RATS
REPAIR OF BONE DEFECTS WITH MARROW-CELLS AND POROUS CERAMIC - EXPERIMENTS IN RATS
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DOI：
10.3109/17453678909149289
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发表时间：
1989-06-01
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影响因子：
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通讯作者：
CAPLAN, AI
中科院分区：
文献类型：
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作者：
OHGUSHI, H;GOLDBERG, VM;CAPLAN, AI
我们研究了骨髓重组多孔陶瓷在促进用刚性聚乙烯钢板固定的5 mm股骨干缺损处愈合中的作用。通过组织学评分评价骨修复情况。单纯植入多孔磷酸钙陶瓷块后1个月，大多数病例在宿主骨-陶瓷交界处有纤维组织植入，术后2个月，12个缺损区中只有4个在近、远侧交界处均有骨性或骨软骨愈合。然而，当陶瓷与同基因存活的骨髓细胞复合时，1个月时陶瓷的孤立孔区出现新的骨形成，2个月后大部分孔区可见广泛的骨形成。12枚种植体中，8枚完全愈合，1枚在术后2个月两侧交界处骨性或骨软骨性愈合。我们的结果表明，多孔磷酸钙陶瓷与骨髓细胞的复合移植可能在临床上应用于增强成骨和骨传导。
We studied the role of bone-marrow reconstituted porous ceramics in enhancing healing of a 5-mm femoral diaphyseal defect fixed with a rigid polyethylene plate in rats. Osseous repair was evaluated by histologic scoring. When blocks of porous calcium phosphate ceramics alone were introduced into the defects, most cases showed fibrous tissue interposition at the host bone-ceramic junction 1 month after implantation, and only four of 12 defects developed osseous or osteochondral union at both the proximal and distal junctions 2 months after surgery. However, when the ceramic was combined with syngeneic viable marrow cells, new bone formation occurred in isolated pore regions of the ceramic at 1 month, and extensive bone formation was seen in most pore regions 2 months after implantation. Out of 12 implants, complete bone union was seen in eight, and one showed osseous or osteochondral union at both junctions 2 months after surgery. Our results indicated that composite grafts of porous calcium phosphate ceramics and marrow cells may be clinically applicable to enhance osteogenesis and osteoconduction.