A Bayesian method for the joint estimation of outcrossing rate and inbreeding depression
A Bayesian method for the joint estimation of outcrossing rate and inbreeding depression
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DOI：
10.1038/hdy.2012.58
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发表时间：
2012-12-01
期刊：
影响因子：
3.8
通讯作者：
Kelly, J. K.
中科院分区：
文献类型：
--
作者：
Koelling, V. A.;Monnahan, P. J.;Kelly, J. K.
群体异交率（t）和成鼠近交系数（F）是交配系统进化的重要参数。根据Ritland（1990）的方法，在给定t和F的情况下，可以估计田间表现出的近交衰退的程度。对于给定的总样本量，t和F的联合估计的最优设计需要对大量的家庭（100-400）进行抽样，每个家庭的后代较少（1-4）。不幸的是，标准推理程序（MLTR）产生显着偏差的估计t和F时，家庭规模小，母亲的基因型是未知的（常见的自然群体抽样时）。在这里，我们提出了一个贝叶斯方法中实现的程序BORICE（贝叶斯异交率和近交系数估计），有效地估计t和F时，家庭规模小，缺乏母亲的基因型信息。BORICE应该能够更广泛地使用Ritland方法，以实地评估近交衰退。作为概念的证明，我们估计t和F在一个自然的人口Mimulus guttatus。此外，我们描述了如何推断BORICE个别母系近亲繁殖的历史可能证明是有用的近亲繁殖及其后果的研究。Heredity（2012）109，393-400; doi：10.1038/hdy.2012.58; 2012年9月19日在线发表
The population outcrossing rate (t) and adult inbreeding coefficient (F) are key parameters in mating system evolution. The magnitude of inbreeding depression as expressed in the field can be estimated given t and F via the method of Ritland (1990). For a given total sample size, the optimal design for the joint estimation of t and F requires sampling large numbers of families (100-400) with fewer offspring (1-4) per family. Unfortunately, the standard inference procedure (MLTR) yields significantly biased estimates for t and F when family sizes are small and maternal genotypes are unknown (a common occurrence when sampling natural populations). Here, we present a Bayesian method implemented in the program BORICE (Bayesian Outcrossing Rate and Inbreeding Coefficient Estimation) that effectively estimates t and F when family sizes are small and maternal genotype information is lacking. BORICE should enable wider use of the Ritland approach for field-based estimates of inbreeding depression. As proof of concept, we estimate t and F in a natural population of Mimulus guttatus. In addition, we describe how individual maternal inbreeding histories inferred by BORICE may prove useful in studies of inbreeding and its consequences. Heredity (2012) 109, 393-400; doi:10.1038/hdy.2012.58; published online 19 September 2012