Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer
Correlation between dynamic contrast-enhanced MRI and quantitative histopathologic microvascular parameters in organ-confined prostate cancer
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DOI：
10.1007/s00330-014-3301-z
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发表时间：
2014-10-01
影响因子：
5.9
通讯作者：
Hulsbergen-van de Kaa, Christina A.
中科院分区：
文献类型：
--
作者：
van Niekerk, Cornelis G.;van der Laak, Jeroen A. W. M.;Hulsbergen-van de Kaa, Christina A.
为了将3-T动态对比增强（DCE-）MRI的药代动力学参数与器官局限性前列腺癌的组织病理学微血管和淋巴参数相关联，在18名在根治性前列腺癌切除术（RP）前接受DCE-MRI的单侧外周区（pT 2a）肿瘤患者中，评估了以下药代动力学参数：渗透性表面积体积传递常数（K（transs））、血管外细胞外体积（Ve）和速率常数（K（ep））。在RP切片中，对血管和淋巴管进行化学可视化，并自动检查和分析。检测指标包括微血管密度（MVD）、面积（MVA）、周长（MVP）和淋巴管密度（LVD）、面积（LVA）、周长（LVP），肿瘤的K（transs）、K（ep）与年龄呈负相关（r =-0.60，p = 0.009; r =-0.67，p = 0.002）和正常（r =-0.54，p = 0.021; r =-0.46，p = 0.055）组织。组织病理学和DCE-MRI微血管参数的绝对值之间无相关性。相比之下，肿瘤和正常组织之间的比率（校正个体微血管变异）在K（ep）和MVD（r = 0.61，p = 0.007）和MVP（r = 0.54，p = 0.022）之间显著相关。淋巴管参数仅与LVA和K（ep）相关（r =-0.66，p = 0.003）。在校正患者间微血管变异时，发现MRI和组织病理学参数。a %正常前列腺组织显示微血管高度异质性。a %外周区前列腺癌显示微血管增多且异质性较低。a %正常而肿瘤组织的微血管分布在不同患者之间有很大的差异，欧洲DCE-MRI应考虑患者之间前列腺微血管的异质性。
To correlate pharmacokinetic parameters of 3-T dynamic contrast-enhanced (DCE-)MRI with histopathologic microvascular and lymphatic parameters in organ-confined prostate cancer.In 18 patients with unilateral peripheral zone (pT2a) tumours who underwent DCE-MRI prior to radical prostatectomy (RP), the following pharmacokinetic parameters were assessed: permeability surface area volume transfer constant (K (trans)), extravascular extracellular volume (Ve) and rate constant (K (ep)). In the RP sections blood and lymph vessels were visualised immunohistochemically and automatically examined and analysed. Parameters assessed included microvessel density (MVD), area (MVA) and perimeter (MVP) as well as lymph vessel density (LVD), area (LVA) and perimeter (LVP).A negative correlation was found between age and K (trans) and K (ep) for tumour (r = -0.60, p = 0.009; r = -0.67, p = 0.002) and normal (r = -0.54, p = 0.021; r = -0.46, p = 0.055) tissue. No correlation existed between absolute values of microvascular parameters from histopathology and DCE-MRI. In contrast, the ratio between tumour and normal tissue (correcting for individual microvascularity variations) significantly correlated between K (ep) and MVD (r = 0.61, p = 0.007) and MVP (r = 0.54, p = 0.022). The lymphovascular parameters showed only a correlation between LVA and K (ep) (r = -0.66, p = 0.003).Significant correlations between DCE-MRI and histopathologic parameters were found when correcting for interpatient variations in microvascularity.aEuro cent Normal prostate tissue shows strong heterogeneity in microvascularity.aEuro cent Peripheral zone prostate cancer shows increased and less heterogeneous microvascularity.aEuro cent Normal and tumour tissue shows considerable variation in microvascularity between patients.aEuro cent DCE-MRI should take into account the interprostatic heterogeneity of microvasculature between patients.