Experimental IgA nephropathy induced by oral immunization.
Experimental IgA nephropathy induced by oral immunization.
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DOI：
10.1084/jem.157.2.572
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发表时间：
1983-02-01
期刊：
影响因子：
--
通讯作者：
Lamm ME
中科院分区：
文献类型：
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作者：
Emancipator SN;Gallo GR;Lamm ME
为了检验 IgA 肾病可能由粘膜免疫反应引起的假设，小鼠口服免疫三种蛋白抗原中的一种，为期 14 周。此类小鼠表现出基本上纯的粘膜抗体反应，其特征在于外分泌部位中产生特异性IgA的浆细胞和血清中特异性IgA抗体。此外，73%的免疫小鼠有IgA，88%的免疫原沉积在肾小球系膜中，超微结构检查的64%的免疫小鼠有电子致密的系膜沉积。 57% 的免疫小鼠体内同时存在这三种情况。对于任何这些参数，免疫小鼠和对照小鼠之间没有观察到 IgG 或 IgM 的差异。因此，粘膜免疫可导致特异性免疫反应，从而导致含有 IgA 抗体的免疫复合物沉积在系膜上。就其基本特征而言，实验性肾损伤类似于人类 IgA 肾病中所见的损伤。
To test the hypothesis that IgA nephropathy can result from a mucosal immune response, mice were orally immunized with one of three protein antigens for 14 wk. Such mice exhibited an essentially pure mucosal antibody response characterized by specific IgA-producing plasma cells in exocrine sites and specific IgA antibodies in serum. Furthermore, 73% of immunized mice had IgA and 88% had immunogen deposited in the glomerular mesangium, and 64% of immunized mice examined ultrastructurally had electron-dense mesangial deposits. All three were present concurrently in 57% of the immunized mice. No differences in regard to IgG or IgM were observed between immunized and control mice for any of these parameters. Mucosal immunization therefore can result in a specific immune response that leads to mesangial deposition of immune complexes containing IgA antibody. In its fundamental features the experimental renal lesion resembles that seen in the human disease IgA nephropathy.