Real-Time Visualization of a Focused Ultrasound Beam Using Ultrasonic Backscatter.
Real-Time Visualization of a Focused Ultrasound Beam Using Ultrasonic Backscatter.
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DOI：
10.1109/tuffc.2020.3035784
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Oelze ML
中科院分区：
文献类型：
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作者：
Thies M;Oelze ML
聚焦超声 (FUS) 疗法利用温度升高或超声波引起的机械应力在局部组织中产生治疗效果。在 FUS 治疗期间，连续监测 FUS 光束的位置至关重要，以便校正组织运动并将焦点保持在目标区域内。为了实现 FUS 治疗实时监测的目标，我们开发了一种使用超声反向散射实时可视化 FUS 波束的方法。 FUS 光束的强度场使用成像阵列接收到的 FUS 脉冲的反向散射进行重建，然后叠加到使用同一成像阵列捕获的 B 模式图像上。 FUS 光束可视化允许人们在周围介质的背景下监控 FUS 光束的位置和范围。通过基于共对准 B 模式图像的回声性进行归一化，在 FUS 光束重建中校正了介质散射特性的变化。平均而言，通过回声归一化将体模非均匀区域中的 FUS 波束重建与基线均匀区域之间的均方误差降低了 21.61。使用单个诊断成像阵列作为 FUS 源和成像探针，在模拟组织模型和大鼠体内肿瘤中实现 FUS 光束可视化，帧速率为 25-30 帧/秒。
Focused ultrasound (FUS) therapies induce therapeutic effects in localized tissues using either temperature elevations or mechanical stresses caused by an ultrasound wave. During an FUS therapy, it is crucial to continuously monitor the position of the FUS beam in order to correct for tissue motion and keep the focus within the target region. Toward the goal of achieving real-time monitoring for FUS therapies, we have developed a method for the real-time visualization of an FUS beam using ultrasonic backscatter. The intensity field of an FUS beam was reconstructed using backscatter from an FUS pulse received by an imaging array and then overlaid onto a B-mode image captured using the same imaging array. The FUS beam visualization allows one to monitor the position and extent of the FUS beam in the context of the surrounding medium. Variations in the scattering properties of the medium were corrected in the FUS beam reconstruction by normalizing based on the echogenicity of the coaligned B-mode image. On average, normalizing by echogenicity reduced the mean square error between FUS beam reconstructions in nonhomogeneous regions of a phantom and baseline homogeneous regions by 21.61. FUS beam visualizations were achieved, using a single diagnostic imaging array as both an FUS source and an imaging probe, in a tissue-mimicking phantom and a rat tumor in vivo with a frame rate of 25–30 frames/s.