Association between dental caries and out-of-hospital cardiac arrests of cardiac origin in Japan
Association between dental caries and out-of-hospital cardiac arrests of cardiac origin in Japan
复制标题
日本龋齿与院外心源性心脏骤停之间的关联
作者：
SUEMATSU;Y.;MIURA;S.;ZHANG;B.;UEHARA;Y.;OGAWA;M.;YONEMOTO;N.;NONOGI;H.;NAGAO;K.;KIMURA;T.;SAKU;K.
研究背景口腔感染与动脉粥样硬化和冠心病有关。我们假设龋齿可能与院外心脏骤停（OHCA）的心源性有关，但与非心源性无关。（785，591例OHCA：55.4%的心源性和44.6%的非心源性）与2005年至2011年日本47个都道府县年龄调整后的龋齿患病率之间的关系。在总人口和65岁以上的男性中，龋齿病例数与2005年至2011年的总和心源性OHCA数量显著相关，但与非心源性OHCA数量无关。在总人群中，年龄调整后的龋齿患病率与年龄调整后的OHCA发病率无显著相关性（总OHCA：r相关系数= 0.22，p = 0.14;心源性OHCA：r= 0.25，p = 0.09;非心源性OHCA：r=-0.002，p = 0.99）。在65岁以上的男性患者中，年龄调整后的龋齿患病率与总OHCA和心源性OHCA显著相关，但与非心源性OHCA无关（总OHCA：r = 0.47，p < 0.001;心源性OHCA：r= 0.37，p = 0.01;非心源性OHCA：r= 0.28，p = 0.054）。
BackgroundOral infection contributes to atherosclerosis and coronary heart disease. We hypothesized that dental caries may be associated with out-of-hospital cardiac arrests (OHCA) of cardiac origin, but not non-cardiac origin.Methods and resultsWe compared the age-adjusted incidence of OHCA (785,591 cases of OHCA: 55.4% of cardiac origin and 44.6% of non-cardiac origin) to the age-adjusted prevalence of dental caries between 2005 and 2011 in the 47 prefectures of Japan. In both the total population and males over 65 years, the number of cases of dental caries was significantly associated with the number of OHCA of total and cardiac origin from 2005 to 2011, but not those of non-cardiac origin. In the total population, the age-adjusted prevalence of dental caries was not significantly associated with the age-adjusted incidence of OHCA (total OHCA:rcorrelation coefficient = 0.22,p= 0.14; OHCA of cardiac origin:r= 0.25,p= 0.09; OHCA of non-cardiac origin:r= −0.002,p= 0.99). Among male patients over 65 years, the age-adjusted prevalence of dental caries was significantly associated with OHCA of total and cardiac origin, but not non-cardiac origin (total OHCA:r= 0.47,p< 0.001; OHCA of cardiac origin:r= 0.37,p= 0.01; OHCA of non-cardiac origin:r= 0.28,p= 0.054).ConclusionsWhile oral hygiene is important in all age groups, it may be particularly associated with OHCAs of cardiac origin in males over 65 years.