Hydrodynamic Phase Locking in Mouse Node Cilia
Hydrodynamic Phase Locking in Mouse Node Cilia
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DOI：
10.1103/physrevlett.110.248107
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发表时间：
2013-06-14
影响因子：
8.6
通讯作者：
Hamada, Hiroshi
中科院分区：
文献类型：
--
作者：
Takamatsu, Atsuko;Shinohara, Kyosuke;Hamada, Hiroshi
小鼠结节纤毛的旋转运动在结节腔内产生向左流动的液体，在胚胎左右决定过程中起着重要作用。尽管许多纤毛的旋转被认为是触发测定所必需的，但最近的报告表明，两根纤毛的作用就足够了。我们通过流体动力相互作用来研究纤毛的协同运动。结果表明，纤毛是相互协作的，具有一定的锁相关系；具有不同纤毛的系统比具有相同纤毛的系统更容易达到锁相状态。
Rotational movement of mouse node cilia generates leftward fluid flow in the node cavity, playing an important role in left-right determination in the embryo. Although rotation of numerous cilia was believed necessary to trigger the determination, recent reports indicate the action of two cilia to be sufficient. We examine cooperative cilia movement via hydrodynamic interaction. Results show cilia to be cooperative, having phases locked in a certain relation; a system with a pair of nonidentical cilia can achieve phase-locked states more easily than one with a pair of identical cilia.