Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis.
Metformin Treatment for the Prevention and/or Treatment of Breast/Mammary Tumorigenesis.
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用于预防和/或治疗乳房/乳腺肿瘤发生的二甲双胍治疗。
DOI：
10.1007/s40495-015-0032-z
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发表时间：
2015
影响因子：
--
通讯作者：
Cleary,MargotP
中科院分区：
文献类型：
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作者：
Grossmann,MichaelE;Yang,Da-Qing;Guo,Zhijun;Potter,DavidA;Cleary,MargotP
人们越来越关注二甲双胍对乳腺癌发生、治疗和/或进展的影响。观察性研究表明，与其他抗糖尿病化合物相比，接受二甲双胍治疗的糖尿病女性乳腺癌发病率和/或死亡率较低。其作用机制被认为是激活肝脏 AMPK，导致糖异生减少。热量限制可以持续减少啮齿动物乳腺肿瘤的发生，也被认为是通过这一途径发挥作用，从而导致二甲双胍的抗癌作用以类似方式介导的假设。在这里，我们回顾了评估二甲双胍与乳腺肿瘤发生相关的抗癌作用的文献。我们包括临床观察以及利用啮齿动物模型和乳腺细胞系的研究。二甲双胍除了通过 AMPK 途径介导的抗癌作用外，还确定了直接靶向组织的其他作用机制，包括对干细胞、细胞凋亡、STAT3 和 HER2 的作用。
There is increasing interest in metformin’s effects on the development, treatment, and/or progression of breast cancer. This emerges from observational studies that diabetic women treated with metformin in comparison to other antidiabetic compounds had lower breast cancer incidence and/or mortality rates. The mechanism of action is considered to be activation of hepatic AMPK resulting in reduced gluconeogenesis. Calorie restriction, which consistently reduces mammary tumorigenesis in rodents, is also thought to act through this pathway leading to the hypothesis that metformin’s anticancer effects are mediated in a similar fashion. Here, we review the literature evaluating metformin’s anticancer effects in relation to breast/mammary tumorigenesis. We include clinical observations, as well as studies utilizing rodent models and mammary cell lines. In addition to the anticancer effect of metformin mediated through the AMPK pathway, additional mechanisms of action that directly target tissues have been identified including effects on stem cells, apoptosis, STAT3, and HER2.