Development of a novel sugar linkage:: 6,6′-ether-connected sugars
Development of a novel sugar linkage:: 6,6′-ether-connected sugars
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DOI：
10.1002/anie.200352388
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发表时间：
2003-01-01
影响因子：
16.6
通讯作者：
Ikegani, S
中科院分区：
文献类型：
--
作者：
Takahashi, H;Fukuda, T;Ikegani, S
不寻常的糖二聚体：描述了通过缩醛化还原程序合成 6, 6'-醚连接的吡喃糖（参见方案）。对这些新型碳水化合物二聚体的结构-活性-关系研究表明，天然产物coyolosa已被证明对空腹血糖水平具有显着影响，但其结构可能与之前报道的不同。
Unusual sugar dimers: The synthesis of 6, 6′-ether-connected pyranoses by an acetalization-reduction procedure is described (see scheme). Structure-activity-relationship studies of these novel carbohydrate dimers suggested that the natural product coyolosa, which has been shown to have a significant effect on fasting blood-glucose levels, may have a different structure from the one previously reported.