Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia : connection to Iatrogenic failure of estrogen secretion
Intractable diffuse alopecia caused by multifactorial side-effects in treatment of acute lymphocytic leukemia : connection to Iatrogenic failure of estrogen secretion
复制标题
急性淋巴细胞白血病治疗中多因素副作用引起的顽固性弥漫性脱发：与医源性雌激素分泌障碍的关系
DOI：
10.1111/j.1525-1470.2011.01692.x
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发表时间：
2011
影响因子：
1.5
通讯作者：
at.El.
中科院分区：
文献类型：
--
作者：
Tomoko Nomiyama;at.El.
婴儿急性淋巴细胞白血病（ALL）的治疗可能会因化疗和全脑放疗诱导的垂体功能减退而导致发育不良和性腺功能减退。我们报告的情况下，一个22岁的女孩与遗传倾向的模式脱发谁开发根深蒂固的弥漫性脱发。患者在8岁时发生ALL，并接受了骨髓移植（BMT）。 她全身逐渐出现弥漫性脱发。她的毫毛逐渐长出来，在BMT后8年时，脱发再次发生。 她后来出现医源性雌激素分泌失败，从20岁开始接受雌激素替代治疗14个月。 在治疗过程中，头发的体积略有增加，但在治疗暂停后，脱发恢复到以前的水平。在雌激素替代治疗期间和暂停治疗2年后进行的头皮组织学检查显示，毛囊数量减少60%，毫毛显著发育。 我们的结论是，雌激素影响头发生长的背景下，遗传易感性模式脱发在这种情况下。
Treatment of infantile acute lymphocytic leukemia (ALL) may cause failure to thrive and hypogonadism due to hypopituitarism induced by chemotherapy and whole‐brain radiotherapy. We report the case of a 22‐year‐old girl with a genetic predisposition to pattern hair loss who developed inveterate diffuse alopecia. The patient had onset of ALL at 8 years old and underwent bone marrow transplantation (BMT). Diffuse alopecia gradually advanced over her whole body. Her vellus scalp hair gradually came out, and hair loss progressed again at 8 years, after BMT. She later developed iatrogenic failure of secretion of estrogen and was treated with estrogen substitution therapy for 14 months from the age of 20. There was a small increase in the volume of hair during therapy, but alopecia returned to the former level after the therapy was suspended. Histopathologic examinations of the scalp performed during estrogen substitution therapy and 2 years after suspension of the therapy showed a 60% decrease in the number of hair follicles and prominent development of vellus hair. We conclude that estrogen influenced hair growth in the context of a genetic predisposition for pattern hair loss in this case.