Pharmacological interventions for lipid transport disorders.
Pharmacological interventions for lipid transport disorders.
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DOI：
10.3389/fnins.2023.1321250
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发表时间：
2023
影响因子：
4.3
通讯作者：
Neiman, Aaron M.
中科院分区：
文献类型：
--
作者：
Neiman, Aaron M.
关键词：
The recent discovery that defects in inter-organelle lipid transport are at the heart of several neurological and neurodegenerative disorders raises the challenge of identifying therapeutic strategies to correct lipid transport defects. This perspective highlights two potential strategies suggested by the study of lipid transport in budding yeast. In the first approach, small molecules are proposed that enhance the lipid transfer activity of VPS13 proteins and thereby compensate for reduced transport. In the second approach, molecules that act as inter-organelle tethers could be used to create artificial contact sites and bypass the loss of endogenous contacts.
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影响因子：
4
作者：
通讯作者：
--
DOI：
10.1177/25152564221125613
发表时间：
2022-01
期刊：
Contact (Thousand Oaks (Ventura County, Calif.))
影响因子：
--
作者：
Chen, Shuliang;Roberts, Melissa A;Chen, Chun-Yuan;Markmiller, Sebastian;Wei, Hong-Guang;Yeo, Gene W;Granneman, James G;Olzmann, James A;Ferro-Novick, Susan
通讯作者：
Ferro-Novick, Susan
DOI：
10.1073/pnas.2008923117
发表时间：
2020-08-04
影响因子：
11.1
作者：
Chen, Shuliang;Mari, Muriel;Ferro-Novick, Susan
通讯作者：
Ferro-Novick, Susan
影响因子：
11.2
作者：
Gauthier, Julie;Meijer, Inge A.;Campeau, Philippe M.
通讯作者：
Campeau, Philippe M.
影响因子：
9.8
作者：
Kolehmainen, J;Black, GCM;Lehesjoki, AE
通讯作者：
Lehesjoki, AE