PROTONMOTIVE REDOX MECHANISM OF CYTOCHROME-B-C1 COMPLEX IN RESPIRATORY-CHAIN - PROTONMOTIVE UBIQUINONE CYCLE
PROTONMOTIVE REDOX MECHANISM OF CYTOCHROME-B-C1 COMPLEX IN RESPIRATORY-CHAIN - PROTONMOTIVE UBIQUINONE CYCLE
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DOI：
10.1016/0014-5793(75)80098-6
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发表时间：
1975-01-01
期刊：
影响因子：
3.5
通讯作者：
MITCHELL, P
中科院分区：
文献类型：
--
作者：
MITCHELL, P
有两个主要的相互关联的困难阻碍了我们对呼吸链细胞色素 b-cl 区域的质子动力和氧化还原功能的理解和理性实验探索的进展，使用正统的生化理论以及经典质子易位氧化还原环的概念设施 [l] 和迄今为止我们明确掌握的该 [l-3] 的一些变体。正如 Slater [4] 所指出的，一个困难是环 3 明显缺乏氢载体。另一个困难是 b 细胞色素的奇特的动力学和热力学行为，它受到了很多关注 [Sl 11，但尚未得到完全令人满意的解释 [12-211]。在本文中，我描述了质子动力 Q* 循环，它提供了基础，既可以解释呼吸链的细胞色素 b-cl 片段的质子转位功能，也可以合理化关于 b 细胞色素和泛醌的行为和功能的许多生化信息，以前似乎很难简单地解释。
There are two major interrelated difficulties that have hampered progress in our understanding and rational experimental exploration of the protonmotive and redox functions of the cytochrome b-cl region of the respiratory chain, using orthodox biochemical theory together with the conceptual facilities of the classical proton-translocating redox loop [l] and some variants of this [l-3] that have so far been explicitly at our disposal. One difficulty is, as pointed out by Slater [4], the apparent lack of a hydrogen carrier for Loop 3. The other difficulty is the peculiar kinetic and thermodynamic behaviour of the b cytochromes, which has received much attention [Sl 11, but not yet a completely satisfactory explanation [12-211.In this paper I describe the protonmotive Q* cycle that provides a basis, both for explaining the protontranslocating function of the cytochrome b-cl segment of the respiratory chain, and for rationalising much of the biochemical information about the behaviour and functions of the b cytochromes and ubiquinone, which previously appeared to be difficult to interpret simply.