COGNITIVE PLANNING DEFICIT IN PATIENTS WITH CEREBELLAR ATROPHY
COGNITIVE PLANNING DEFICIT IN PATIENTS WITH CEREBELLAR ATROPHY
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DOI：
10.1212/wnl.42.8.1493
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发表时间：
1992-08-01
期刊：
影响因子：
9.9
通讯作者：
HALLETT, M
中科院分区：
文献类型：
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作者：
GRAFMAN, J;LITVAN, I;HALLETT, M
我们比较了12名小脑萎缩（CA）患者和12名年龄和教育程度相匹配的正常对照组在河内塔上的表现，这是一项需要认知规划的9个问题的任务。CA患者在这项任务上的表现显着不如对照组，尽管在计划和移动之间的停顿时间没有差异。仅使用纯小脑皮质萎缩（CCA）患者亚组（N = 9）对数据进行重新分析，重复了上述结果，并显示CCA患者与对照组相比计划时间显著增加。无论是年龄，性别，教育水平，痴呆的严重程度，文字流畅性，反应时间，记忆，也不是视觉程序学习预测CA或CCA性能。这种认知计划的缺陷表明小脑、基底神经节和额叶之间关于特定认知过程的功能联系。然而，小脑在认知规划中的确切作用仍然没有确定。
We compared the performance of 12 patients with cerebellar atrophy (CA) and 12 normal controls matched for age and education on the Tower of Hanoi, a nine-problem task that requires cognitive planning. CA patients performed significantly worse than controls on this task despite no difference in planning and between-move pause times. A reanalysis of the data using just the subgroup of patients with pure cerebellar cortical atrophy (CCA) (N = 9) replicated the above results and also showed that CCA patients had significantly increased planning times compared with controls. Neither age, sex, education level, severity of dementia, word fluency, response time, memory, nor visuomotor procedural learning predicted CA or CCA performance. This deficit in cognitive planning suggests a functional link between the cerebellum, basal ganglia, and the frontal lobe concerning specific cognitive processes. However, the exact role of the cerebellum in cognitive planning remains undetermined.