Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis
Multiparametric magnetic resonance imaging analysis of the corticospinal tract in multiple sclerosis
复制标题
DOI：
10.1016/j.neuroimage.2007.07.049
复制
发表时间：
2007-11-01
期刊：
影响因子：
5.7
通讯作者：
Calabresi, Peter A.
中科院分区：
文献类型：
--
作者：
Reich, Daniel S.;Smith, Seth A.;Calabresi, Peter A.
背景/目的：肌肉无力是多发性硬化症的一个重要特征，并且是与该病症相关的大部分残疾的原因。在这里，我们描述了定量磁共振成像（MRI）的主要脑内运动通路-皮质脊髓束-多发性硬化症的属性。为此，我们开发了一种直观的方法来创建和显示空间标准化的特定束成像数据。方法：在75名多发性硬化症患者和29名健康对照者中，通过3 T的扩散张量成像重建皮质脊髓束。多个MRI指标- T2弛豫时间;分数各向异性;平均，纵向和横向扩散率;和磁化传递比-进行了检查重建的管道内。空间标准化的道配置文件创建比较，跨学科，在MRI指数的变化作为一个函数的道position.Results：每个指数的道配置文件有一个特征的形状。个别受试者有显着异常的管道配置文件，特别是在病变部位。平均而言，患者和对照组之间的束轮廓是不同的，特别是在皮质下白色物质和放射冠，除了分数各向异性检查的所有指标。在继发性疾病进展的受试者中，磁化传递率进一步降低。多发性硬化症的不对称性增加controls.Conclusion：多参数MRI可以快速检测，定位和表征多发性硬化症的特定异常。脑道剖面在神经系统疾病的全脑成像和个体功能相关子系统的询问之间架起了差距的桥梁。(C)2007爱思唯尔公司All rights reserved.
Background/purpose: Muscle weakness is an important feature of multiple sclerosis and is responsible for much of the disability associated with that condition. Here, we describe the quantitative magnetic resonance imaging (MRI) attributes of the major intracerebral motor pathway - the corticospinai tract - in multiple sclerosis. To do so, we develop an intuitive method for creating and displaying spatially normalized tract-specific imaging data.Methods: In 75 individuals with multiple sclerosis and 29 healthy controls, the corticospinal tracts were reconstructed from diffusion tensor imaging at 3 T. Multiple MRI indices - T2 relaxation time; fractional anisotropy; mean, longitudinal, and transverse diffusivity; and magnetization transfer ratio - were examined within the reconstructed tracts. Spatially normalized tract profiles were created to compare, across subjects, the variation in MRI index as a function of tract position.Results: Each index's tract profile had a characteristic shape. Individual subjects had markedly abnormal tract profiles, particularly at lesion sites. On average, tract profiles were different between patients and controls, particularly in the subcortical white matter and corona radiata, for all indices examined except for fractional anisotropy. Magnetization transfer ratio was further decreased in subjects with secondary progressive disease. Tract asymmetry was increased in multiple sclerosis compared to controls.Conclusion: Multiparametric MRI allows rapid detection, localization, and characterization of tract-specific abnormalities in multiple sclerosis. Tract profiles bridge the gap between whole-brain imaging of neurological disease and the interrogation of individual, functionally relevant subsystems. (C) 2007 Elsevier Inc. All rights reserved.