Human herpesviruses in chronic fatigue syndrome.
Human herpesviruses in chronic fatigue syndrome.
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慢性疲劳综合症中的人类疱疹病毒。
DOI：
10.1128/cdli.6.2.216-223.1999
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hay,J
中科院分区：
文献类型：
--
作者：
Wallace2nd,HL;Natelson,B;Gause,W;Hay,J
我们进行了一项双盲研究，以评估与年龄、种族和性别匹配的对照组相比，人类疱疹病毒（HHV）HHV 6、HHV 7、EB病毒（EBV）和巨细胞病毒在慢性疲劳综合征（CFS）患者中的可能参与。CFS患者人群由严格筛选的符合疾病控制和预防中心CFS病例定义标准的平民和波斯湾战争退伍军人组成。健康对照的平民和退伍军人群体没有CFS或任何其他排除性医疗或精神疾病的证据。通过PCR分析患者外周血单核细胞中是否存在这些HHV。使用双尾Fisher精确检验分析，我们无法确定CFS患者和对照人群在检测一种或多种这些病毒方面的任何统计学显著差异。当CFS人群根据是否存在主轴I精神病理学和患者自我报告的疾病逐渐发作与急性发作进一步分层时，这一观察结果得到了支持。在串联，我们进行了血清抗EBV和抗HHV6抗体滴度的血清学分析，发现CFS和对照组患者之间没有显着差异。
We have conducted a double-blind study to assess the possible involvement of the human herpesviruses (HHVs) HHV6, HHV7, Epstein-Barr virus (EBV), and cytomegalovirus in chronic fatigue syndrome (CFS) patients compared to age-, race-, and gender-matched controls. The CFS patient population was composed of rigorously screened civilian and Persian Gulf War veterans meeting the Centers for Disease Control and Prevention’s CFS case definition criteria. Healthy control civilian and veteran populations had no evidence of CFS or any other exclusionary medical or psychiatric condition. Patient peripheral blood mononuclear cells were analyzed by PCR for the presence of these HHVs. Using two-tailed Fisher’s exact test analyses, we were unable to ascertain any statistically significant differences between the CFS patient and control populations in terms of the detection of one or more of these viruses. This observation was upheld when the CFS populations were further stratified with regard to the presence or absence of major axis I psychopathology and patient self-reported gradual versus acute onset of disease. In tandem, we performed serological analyses of serum anti-EBV and anti-HHV6 antibody titers and found no significant differences between the CFS and control patients.