High-quality life extension by the enzyme peptide methionine sulfoxide reductase
High-quality life extension by the enzyme peptide methionine sulfoxide reductase
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DOI：
10.1073/pnas.032671199
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发表时间：
2002-03-05
影响因子：
11.1
通讯作者：
Hoshi, T
中科院分区：
文献类型：
--
作者：
Ruan, H;Tang, XD;Hoshi, T
对细胞成分的累积性氧化损伤被认为有助于衰老和与年龄相关的疾病。肽甲硫氨酸亚砜还原酶A（MSRA）通过将甲硫氨酸亚砜还原回甲硫氨酸来催化蛋白质中氧化甲硫氨酸的修复。然而，MSRA是否在衰老过程中发挥作用还知之甚少。在这里，我们报告说，主要在神经系统中的msrA基因的过度表达显着延长果蝇的寿命。MSRA转基因动物对百草枯诱导的氧化应激具有更强的抵抗力，衰老诱导的一般活动水平和生殖能力下降的开始明显延迟。结果表明，氧化损伤是寿命的重要决定因素，MSRA可能在增加包括人类在内的其他生物体的寿命方面很重要。
Cumulative oxidative damages to cell constituents are considered to contribute to aging and age-related diseases. The enzyme peptide methionine sulfoxide reductase A (MSRA) catalyzes the repair of oxidized methionine in proteins by reducing methionine sulfoxide back to methionine. However, whether MSRA plays a role in the aging process is poorly understood. Here we report that overexpression of the msrA gene predominantly in the nervous system markedly extends the lifespan of the fruit fly Drosophila. The MSRA transgenic animals are more resistant to paraquat-induced oxidative stress, and the onset of senescence-induced decline in the general activity level and reproductive capacity is delayed markedly. The results suggest that oxidative damage is an important determinant of lifespan, and MSRA may be important in increasing the lifespan in other organisms including humans.