Diet-induced changes in serum cholesterol concentrations do not alter tryptophan hydroxylation rate or serotonin concentrations in gerbil brain.
Diet-induced changes in serum cholesterol concentrations do not alter tryptophan hydroxylation rate or serotonin concentrations in gerbil brain.
复制标题
饮食引起的血清胆固醇浓度变化不会改变沙鼠大脑中的色氨酸羟化率或血清素浓度。
DOI：
10.1016/0024-3205(96)00113-0
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发表时间：
1996
期刊：
影响因子：
6.1
通讯作者：
Fernstrom,JD
中科院分区：
文献类型：
--
作者：
Fernstrom,MH;Verrico,CD;Ebaugh,AL;Fernstrom,JD
在长期饲喂含20%脂肪(红花油、牛脂或乳脂)的饲料中添加或不添加胆固醇(0.5%，干重)，研究了血清胆固醇浓度与脑内5-羟色胺合成率的关系。这些饮食22天后，循环中的胆固醇浓度在~1.5到~20微克分子/毫升之间变化，尽管变化幅度很大，但体内色氨酸羟化率以及大脑皮层、下丘脑和脑干中的5-羟色胺和5-羟吲哚乙酸浓度在不同饮食组之间没有显著差异。血清和大脑中的色氨酸浓度也没有受到影响。这些结果不支持这样一种假设，即抑郁、自杀和暴力死亡与人类血清胆固醇浓度低于正常或降低之间的联系涉及脑神经元5-羟色胺合成和/或释放的变化。
The relationship between serum cholesterol concentrations and serotonin synthesis rate in brain was examined in Mongolian gerbils chronically fed diets containing 20% fat (safflower oil, beef tallow or butterfat) with or without added cholesterol (0.5%, dry weight). After 22 days on these diets, circulating cholesterol concentrations ranged between ~1.5 and ~20 umol/ml. Despite this enormous range, in vivo tryptophan hydroxylation rate, and serotonin and 5-hydroxyindoleacetic acid concentrations in cerebral cortex, hypothalamus and brainstem did not differ significantly among the diet groups. Tryptophan concentrations in serum and brain were also unaffected. These results do not support the hypothesis that the link between depression, suicide and violent deaths and below-normal or reduced serum cholesterol concentrations in humans involves an alteration in serotonin synthesis and/or release by brain neurons.