HOMOLOGOUS GENES ENCODE 2 DISTINCT HISTIDINE-RICH PROTEINS IN A CLONED ISOLATE OF PLASMODIUM-FALCIPARUM
HOMOLOGOUS GENES ENCODE 2 DISTINCT HISTIDINE-RICH PROTEINS IN A CLONED ISOLATE OF PLASMODIUM-FALCIPARUM
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DOI：
10.1073/pnas.83.16.6065
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发表时间：
1986-08-01
影响因子：
11.1
通讯作者：
HOWARD, RJ
中科院分区：
文献类型：
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作者：
WELLEMS, TE;HOWARD, RJ
两个基因编码不同的组氨酸丰富的蛋白质在疟原虫flaciparum克隆表现出高水平的同源性，这表明他们起源于从一个共同的祖先序列的重复和分歧。这两个基因具有相似的中断结构和编码非常高的组氨酸和丙氨酸含量的密切相关的串联重复序列的外显子。由一个基因编码的最常见的重复序列，六肽Ala-His-His-Ala-Ala-Asp，在第六位不同于由另一个基因编码的最常见的重复序列，六肽Ala-His-His-Ala-Ala-Asn。重复结构域的趋异大于侧翼区的趋异，侧翼区表现出85-90%的同源性，包括非翻译序列。这表明串联重复序列是基因组中相对不稳定的元件，可能为寄生虫提供了快速进化的手段。
Two genes encoding distinct histidine-rich proteins in a Plasmodium flaciparum clone exhibit high levels of homology, suggesting they have originated by duplication and divergence from a common ancestral sequence. Both genes have a similar interrupted structure and an exon that encodes closely related tandom repeats of very high histidine and alanine content. The most common repeat encoded by one gene, the hexapeptide Ala-His-His-Ala-Ala-Asp, differs in the sixth position from the most common repeat encoded by the other gene, the hexapeptide Ala-His-His-Ala-Ala-Asn. The divergence of the repeat domains is greater than that of the flanking regions, which exhibit 85-90% homology, including untranslated sequences. This suggests the tandem repeats are relatively labile elements within the genome that may provide the parasite with a means of rapid evolutionary change.