Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions
Sperm disintegrins, egg integrins, and other cell adhesion molecules of mammalian gamete plasma membrane interactions
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DOI：
10.2741/evans
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发表时间：
1999-01-15
期刊：
影响因子：
--
通讯作者：
Evans, Janice P.
中科院分区：
文献类型：
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作者：
Evans, Janice P.
精子和卵子之间发生的细胞-细胞相互作用不仅涉及配子质膜的结合，而且还涉及配子质膜的融合。几十年前和最近进行的大量研究表明，精子和卵子上的几个不同分子参与了配子膜的相互作用。最近最受关注的精子蛋白与去整合素有同源性，去整合素是蛇毒中可以与整合素相互作用的蛋白质。这些精子去整合素样蛋白是一个分子家族的成员，被称为亚当(A去整合素和A金属蛋白)或MDC(金属蛋白酶，去整合素，富含半胱氨酸)。本综述将重点介绍与哺乳动物精子-卵子结合或配子膜融合有关的分子。将讨论的分子包括精子上的ADAM/MDC家族的三个成员(受精素α、受精素β和胱氨酸蛋白)，卵子上的整合素(α-6/β-1和其他)，以及一些在其他系统中新发现并具有特征的其他卵子和精子分子，这些分子与这些过程有关。
The cell-cell interactions that occur between sperm and egg involve not only the binding but also the fusion of the gamete plasma membranes. Numerous studies, carried out decades ago and more recently, have implicated several different molecules on both the sperm and egg as being involved in gamete membrane interactions. The sperm proteins that have received the most attention recently have homology to disintegrins, which are proteins in snake venoms that can interact with integrins. These sperm disintegrin-like proteins are members of a molecular family, known as ADAM's (for A Disintegrin and A Metalloprotease) or MDC's (for Metalloprotease, Disintegrin, Cysteine-rich). This review will focus on the molecules that have been implicated in mediating mammalian sperm-egg binding or the fusion of the gamete membranes. The molecules that will be discussed include three members of the ADAM/MDC family on sperm (fertilin alpha, fertilin beta, and cyritestin), integrins on eggs (alpha-6/beta-1 and others), and a number of other egg and sperm molecules, novel and characterized in other systems, that have been implicated in these processes.