Cracking the host functional network involved in hepatitis B virus cccDNA biology.
Cracking the host functional network involved in hepatitis B virus cccDNA biology.
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破解参与B型肝炎病毒cccDNA生物学的宿主功能网络。
DOI：
10.1136/gutjnl-2022-329185
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发表时间：
2023-09
期刊：
影响因子：
24.5
通讯作者：
Ploss, Alexander
中科院分区：
文献类型：
--
作者：
Testoni, Barbara;Ploss, Alexander
B型肝炎病毒（HBV）在全世界至少2.5亿人中引起慢性感染，每年导致约85万人死亡。慢性携带者有患严重肝病的风险，包括失代偿性肝硬化和肝细胞癌（HCC）。HBV感染可以通过高效的预防性疫苗来预防。病毒血症可以用靶向HBV聚合酶的核苷/核苷类似物抑制，但标准治疗很少导致治愈，患者需要终身治疗以防止病毒复制复发。此外，即使在治疗中，患者仍有发生HCC的剩余风险。由于我们对HBV持久性的不完全理解以及难以靶向病毒复制周期中的关键步骤，导致功能性治愈的治疗方法的开发受到阻碍。1 HBV是嗜肝DNA病毒科的一种部分双链DNA病毒，具有复杂的复制周期，并与宿主细胞DNA修复机制错综复杂地交织在一起（图1）。在受体介导的内吞作用后，B型肝炎病毒体携带一种形式的基因组进入宿主细胞，即人肝细胞，称为松弛环状DNA（rcDNA）。rcDNA是一种携带病变的分子，必须修复，
Hepatitis B virus (HBV) causes chronic infection in at least 250 million people worldwide, resulting in approximately 850 000 deaths annually. Chronic carriers are at risk of developing severe liver disease including decompensated cirrhosis and hepatocellular carcinoma (HCC). HBV infection can be prevented with a highly effective prophylactic vaccine. Viraemia can be suppressed with nucleos/tide analogues targeting the HBV polymerase, but standard-of-care therapy rarely leads to a cure leaving patients requiring lifelong therapy to prevent relapse of viral replication. Furthermore, even on treatment patients remain at a residual risk of developing HCC. Development of treatments resulting in a functional cure has been hampered by our incomplete understanding of HBV persistence and the difficulty of targeting pharmacologically essential steps in the viral replicative cycle. 1 HBV is a partially double-stranded DNA virus of the Hepadnaviridae family, which has a complex replication cycle and is intricately intertwined with the host cell DNA repair machinery (figure 1). Following receptor-mediated endocytosis, hepatitis B virions carry a form of the genome into the host cell, the human hepatocyte, referred to as relaxed circular DNA (rcDNA). rcDNA is a lesion-bearing molecule, which must be repaired to
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影响因子：
7.6
作者：
Cai, Dawei;Wang, Xiaohe;Yan, Ran;Mao, Richeng;Liu, Yuanjie;Ji, Changhua;Cuconati, Andrea;Guo, Haitao
通讯作者：
Guo, Haitao
影响因子：
6.7
作者：
Tang, Liudi;Sheraz, Muhammad;Guo, Ju-Tao
通讯作者：
Guo, Ju-Tao
DOI：
10.3390/v13081463
发表时间：
2021-07-27
期刊：
Viruses
影响因子：
--
作者：
Wei L;Ploss A
通讯作者：
Ploss A
DOI：
10.1016/j.jcmgh.2022.05.007
发表时间：
2022
影响因子：
7.2
作者：
Locatelli, Maelle;Quivy, Jean-Pierre;Chapus, Fleur;Michelet, Maud;Fresquet, Judith;Maadadi, Sarah;Aberkane, Amel Neila;Diederichs, Audrey;Lucifora, Julie;Rivoire, Michel;Almouzn, Genevieve;Testoni, Barbara;Zoulim, Fabien
通讯作者：
Zoulim, Fabien
影响因子：
16.6
作者：
Wei L;Ploss A
通讯作者：
Ploss A