Habitual salt intake and risk of gastric cancer: A meta-analysis of prospective studies
Habitual salt intake and risk of gastric cancer: A meta-analysis of prospective studies
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DOI：
10.1016/j.clnu.2012.01.003
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发表时间：
2012-08-01
影响因子：
6.3
通讯作者：
Strazzullo, Pasquale
中科院分区：
文献类型：
--
作者：
D'Elia, Lanfranco;Rossi, Giovanni;Strazzullo, Pasquale
背景与目的：评价膳食盐摄入量与胃癌之间关系的病例对照研究的系统综述显示两者呈正相关，但缺乏纵向队列研究的定量分析。因此，我们进行了一项荟萃分析，以评估前瞻性研究中习惯性盐摄入量与胃癌风险之间的关系。方法：我们对已发表的文章（1966-2010）进行了系统检索。纳入标准为：原创文章、前瞻性成人人群研究、盐摄入量作为基线暴露和胃癌作为结果的评估、至少4年的随访、暴露的参与者数量和不同盐摄入类别的事件。结果：7项研究（10个队列）符合纳入标准（268 718名受试者，1474个事件，随访6-15年）。在汇总分析中，“高”、“中高”与“低”盐摄入量均与胃癌风险增加相关（RR = 1.68 [95% ci 1.17-2.41], p = 0.005，分别为1.41 [1.03-1.93],p = 0.032），无发表偏倚证据。这种关联在日本人群中更为明显，而且选择高盐食品的高摄入量也与更高的风险相关。meta回归分析没有发现异质性的具体来源。结论：在前瞻性人群研究中，膳食盐摄入量与胃癌的风险直接相关，并且随着摄入水平的增加，风险逐渐增加。(C) 2012爱思唯尔有限公司和欧洲临床营养与代谢学会。版权所有。
Background & aims: Systematic reviews of case-control studies evaluating the relationship between dietary salt intake and gastric cancer showed a positive association, however a quantitative analysis of longitudinal cohort studies is lacking. Therefore, we carried out a meta-analysis to assess the association between habitual salt intake and risk of gastric cancer in prospective studies.Methods: We performed a systematic search of published articles (1966-2010). Criteria for inclusion were: original articles, prospective adult population studies, assessment of salt intake as baseline exposure and of gastric cancer as outcome, follow-up of at least 4 years, indication of number of participants exposed and events across different salt intake categories.Results: Seven studies (10 cohorts) met the inclusion criteria (268 718 participants, 1474 events, follow-up 6-15 years). In the pooled analysis, "high" and "moderately high" vs "low" salt intake were both associated with increased risk of gastric cancer (RR = 1.68 [95% C.I. 1.17-2.41], p = 0.005 and respectively 1.41 [1.03-1.93], p = 0.032), with no evidence of publication bias. The association was stronger in the Japanese population and higher consumption of selected salt-rich foods was also associated with greater risk. Meta-regression analyses did not detect specific sources of heterogeneity.Conclusions: Dietary salt intake was directly associated with risk of gastric cancer in prospective population studies, with progressively increasing risk across consumption levels. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.