Low-dose neuroleptic treatment of outpatient schizophrenics. I. Preliminary results for relapse rates.
Low-dose neuroleptic treatment of outpatient schizophrenics. I. Preliminary results for relapse rates.
复制标题
门诊精神分裂症患者的低剂量精神安定药治疗。
作者：
J. Kane;A. Rifkin;M. Woerner;Reardon Gt;S. Sarantakos;D. Schiebel;J. Ramos
为了开始建立精神分裂症维持治疗的最低有效剂量要求，我们在门诊精神分裂症患者中进行了低剂量氟奋乃静癸酸酯（1.25至5.0 mg/2 wk）与标准剂量方案（12.5至50.0 mg/2 wk）的双盲比较。对于研究的前126名患者，低剂量组一年的累积复发率为56%，标准剂量组为7%，差异显著。尽管在整个样本中几乎没有发生运动障碍，但低剂量治疗似乎在产生更少的迟发性运动障碍早期体征方面具有显著优势。还考虑了复发的严重程度和总累积剂量。
In an attempt to begin to establish minimum effective dosage requirements for the maintenance treatment of schizophrenia, we undertook a double-blind comparison of low-dose fluphenazine decanoate (1.25 to 5.0 mg/2 wk) with the standard-dose regimen (12.5 to 50.0 mg/2 wk) in outpatient schizophrenics. For the first 126 patients studied, cumulative relapse rates at one year for the low dose were 56% and for the standard dose 7%, a significant difference. Despite the fact that very little dyskinetic symptomatology developed in the sample as a whole, the low-dose treatment appeared to have a significant advantage in producing fewer early signs of tardive dyskinesia. Severity of relapse and total cumulative dosage were also considered.