Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study
Aberrant cortical gyrification in schizophrenia: a surface-based morphometry study
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DOI：
10.1503/jpn.110119
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发表时间：
2012-11-01
影响因子：
4.3
通讯作者：
Liddle, Peter F.
中科院分区：
文献类型：
--
作者：
Palaniyappan, Lena;Liddle, Peter F.
背景：精神分裂症被认为是一种与皮质发育障碍相关的大脑连接障碍。在皮层成熟的早期，连接性的紊乱会导致脑回化的广泛缺陷。研究脑回发育缺陷的解剖分布可以为精神分裂症患者的神经发育提供重要信息。研究方法：我们对覆盖整个皮质的多个顶点的三维重建皮质表面进行了基于表面的脑回化自动形态测量评估。我们使用的样本来自我们以前的研究57例精神分裂症患者（50名男性）和41名对照组（39名男性），我们已经测试了一个特定的假设，即使用额叶感兴趣区域的方法在前额皮质中存在低回和高回。结果如下：脑回化显著减少的区域（脑回减少）主要见于左半球，涉及多模态联合皮层的前额叶和几个区域。尽管先前记录的前额皮质过度回动在全脑搜索所需的统计学校正中没有存活下来（在p = 0.0001处包含簇），但是当阈值降低时，出现了显著的过度回动额叶簇（在p = 0.05处包含簇）。在研究中，精神分裂症患者脑回化的减少与皮质厚度的减少有关。局限性：我们研究了服用抗精神病药物的患者样本，这可能会混淆结果。我们的样本主要是男性，这限制了我们发现的普遍性。结论：我们的观察结果表明，在精神分裂症患者中看到的皮质回化的干扰可能与边缘和多模态关联皮质之间的相互作用中断，从而可能有助于疾病的发病机制。
Background: Schizophrenia is considered to be a disorder of cerebral connectivity associated with disturbances of cortical development. Disturbances in connectivity at an early period of cortical maturation can result in widespread defects in gyrification. Investigating the anatomic distribution of gyrification defects can provide important information about neurodevelopment in patients with schizophrenia. Methods: We undertook an automated surface-based morphometric assessment of gyrification on 3-dimensionally reconstructed cortical surfaces across multiple vertices that cover the entire cortex. We used a sample from our previous research of 57 patients (50 men) with schizophrenia and 41 controls (39 men) in whom we had tested a specific hypothesis regarding presence of both hypo-and hypergyria in the prefrontal cortex using a frontal region-of-interest approach. Results: Regions with significant reductions in gyrification (hypogyria) were seen predominantly in the left hemisphere, involving the insula and several regions of the multimodal association cortex. Although the prefrontal hypergyria documented earlier did not survive the statistical correction required for a whole brain search (cluster inclusion at p = 0.0001), significant hypergyric frontal clusters emerged when the threshold was lowered (cluster inclusion at p = 0.05). In the insula, a reduction in gyrification was related to reduced cortical thickness in patients with schizophrenia. Limitations: We studied a sample of patients taking antipsychotic medications, which could have confounded the results. Our sample was predominantly male, limiting the generalizability of our findings. Conclusion: Our observations suggest that the disturbances in cortical gyrification seen in patients with schizophrenia might be related to a disrupted interaction between the paralimbic and the multimodal association cortex and thus might contribute to the pathogenesis of the illness.