Proteases of an early colonizer can hinder Streptococcus mutans colonization in vitro.
Proteases of an early colonizer can hinder Streptococcus mutans colonization in vitro.
复制标题
早期定植者的蛋白酶可以阻碍变形链球菌的体外定植。
DOI：
10.1177/0022034510388808
复制
发表时间：
2011
影响因子：
7.6
通讯作者：
Kuramitsu,HK
中科院分区：
文献类型：
--
作者：
Wang,B-Y;Deutch,A;Hong,J;Kuramitsu,HK
Streptococcus mutansis the primary cariogen that produces several virulence factors that are modulated by a competence-stimulating peptide (CSP) signaling system. In this study, we sought to determine if proteases produced by early dental plaque colonizers such asStreptococcus gordoniiinterfere with the subsequent colonization ofS. mutansBM71 on the existing streptococcal biofilms. We demonstrated thatS. mutansBM71 colonized much less efficientlyin vitroon streptococcal biofilms than onActinomyces naeslundiibiofilms. Several oral streptococci, relative toA. naeslundii, produced proteases that inactivated theS. mutansCSP. We further demonstrated that cell protein extracts fromS. gordonii, but not fromA. naeslundii, interfered withS. mutansBM71 colonization. In addition,S. mutansBM71 colonized more efficiently on thesgcprotease knockout mutant ofS. gordoniithan on the parent biofilms. In conclusion, proteases of early colonizers can interfere with subsequent colonization byS. mutansin vitro.
