Exposure to ultraviolet radiation and risk of malignant lymphoma and multiple myeloma -: a multicentre European case-control study
Exposure to ultraviolet radiation and risk of malignant lymphoma and multiple myeloma -: a multicentre European case-control study
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DOI：
10.1093/ije/dyn092
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发表时间：
2008-10-01
影响因子：
7.7
通讯作者：
Brennan, Paul
中科院分区：
文献类型：
--
作者：
Boffetta, Paolo;van der Hel, Olga;Brennan, Paul
背景 最近的三项研究报告了高紫外线 (UV) 辐射暴露可降低非霍奇金淋巴瘤 (NHL) 的风险。 方法 我们在 1998 年至 2004 年期间在法国、德国、爱尔兰、意大利和西班牙进行了一项多中心病例对照研究，其中包括 1518 例 NHL 病例、268 例霍奇金淋巴瘤病例、242 例多发性骨髓瘤病例和 2124 例人群或医院对照。我们通过访谈收集了儿童期和成年期对阳光的敏感性和个人暴露于紫外线辐射的信息，并从职业史中评估了紫外线辐射的职业暴露。 结果 皮肤对阳光的敏感性增加，霍奇金和 NHL 的风险就会增加 [比值比 (OR) 没有晒黑与非常棕色 2.35，95% CI 0.94-5.87 和 1.39，95% CI 1.03-1.87，分别]。成人个人暴露（自由日暴露的最高与最低四分位数的 OR 为 0.62，95% CI 0.44-0.87）和紫外线辐射职业暴露（最高与最低暴露四分位的 OR 为 0.63，95% CI 0.37-1.04）的增加，弥漫性大 B 细胞淋巴瘤的风险降低。成年期间个人暴露于紫外线辐射会增加患多发性骨髓瘤的风险（自由日暴露于紫外线辐射的最高与最低四分位数的 OR 为 1.49，95% CI 0.88-2.50）。观察到使用太阳灯对弥漫性大 B 细胞淋巴瘤有保护作用（25 次以上的 OR 与从不 0.63，95% CI 0.38-1.03）。 结论 我们的结果支持紫外线辐射对淋巴瘤有保护作用的假设。潜在的机制可能与皮肤癌发生的机制不同。多发性骨髓瘤风险增加值得复制。
Background Three recent studies have reported a decreased risk of non-Hodgkin lymphoma (NHL) for high ultraviolet (UV) radiation exposure.Methods We conducted a multicentre casecontrol study during 1998-2004 in France, Germany, Ireland, Italy and Spain, comprising 1518 cases of NHL, 268 cases of Hodgkin lymphoma, 242 cases of multiple myeloma and 2124 population or hospital controls. We collected information on sensitivity to sun and personal exposure to UV radiation in childhood and adulthood via interview, and assessed occupational exposure to UV radiation from the occupational history.Results The risk of Hodgkin and NHL was increased for increasing skin sensitivity to the sun [odds ratio (OR) for no suntan vs very brown 2.35, 95% CI 0.94-5.87 and 1.39, 95% CI 1.03-1.87, respectively]. The risk of diffuse large B-cell lymphoma was reduced for increasing adult personal (OR for highest vs lowest quartile of exposure in free days 0.62, 95% CI 0.44-0.87) and for occupational exposure to UV radiation (OR for highest vs lowest exposure tertile 0.63, 95% CI 0.37-1.04). The risk of multiple myeloma was increased for personal exposure to UV radiation during adulthood (OR for highest vs lowest quartile of exposure in free days 1.49, 95% CI 0.88-2.50). A protective effect was observed for use of sun lamps for diffuse large B-cell lymphoma (OR for 25 + times vs never 0.63, 95% CI 0.38-1.03).Conclusions The hypothesis of a protective effect of UV radiation on lymphoma is supported by our results. The underlying mechanisms might differ from those operating in skin carcinogenesis. The increased risk of multiple myeloma is worth replication.