Functional network in the prefrontal cortex during episodic memory retrieval
Functional network in the prefrontal cortex during episodic memory retrieval
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DOI：
10.1016/j.neuroimage.2005.03.004
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发表时间：
2005-07
期刊：
影响因子：
5.7
通讯作者：
S. Umeda;Y. Akine;Motoichiro Kato;Taro Muramatsu;M. Mimura;S. Kandatsu;S. Tanada;T. Obata;H. Ikehira;T. Suhara
中科院分区：
文献类型：
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作者：
S. Umeda;Y. Akine;Motoichiro Kato;Taro Muramatsu;M. Mimura;S. Kandatsu;S. Tanada;T. Obata;H. Ikehira;T. Suhara
最近在人类记忆的神经成像研究中一致发现，前额叶皮层（PFC）在情景记忆检索过程中被激活。然而，到目前为止，还没有直接的证据来解释左右PFC以及前后PFC的活动是如何在功能上相互联系的。本研究的目的是通过事件相关功能磁共振成像（MRI）和功能连接方法来获得这些证据。实验对象首先被要求在核磁共振扫描仪外试着记住一系列相关单词列表，为之后的识别测试做准备。在MRI扫描阶段，他们被要求对旧词、语义相关的诱惑词和不相关的新词做出识别判断。功能连通性分析显示，每个半球的后PFC与对侧后PFC有很强的功能联系，而每个半球的前PFC与对侧前PFC只有弱的功能联系，两个半球的前、后PFC之间均未发现强的功能联系。这些发现支持了双侧PFC后部对情景记忆检索的联想贡献和双侧PFC前部的解离贡献的假设。
A recent consistent finding in neuroimaging studies of human memory is that the prefrontal cortex (PFC) is activated during episodic memory retrieval. To date, however, there has been no direct evidence to explain how activity in the right and left PFC and in the anterior and posterior PFC are functionally interconnected. The goal of the present study was to obtain such evidence by event-related functional magnetic resonance imaging (MRI) and the functional connectivity method. Subjects were first asked to try to remember a series of associate-word lists outside the MRI scanner in preparation for a later recognition test. In the MRI scanning phase, they were asked to make recognition judgments in regard to old words, semantically related lure words, and unrelated new words. The analysis of functional connectivity revealed that the posterior PFC in each hemisphere had strong functional interconnections with the contralateral posterior PFC, whereas the anterior PFC in each hemisphere had only weak functional interconnections with the contralateral anterior PFC. No strong functional interconnections were found between the anterior and posterior PFC in either hemisphere. These findings support the hypothesis of an associative contribution of the bilateral posterior PFC to episodic memory retrieval and a dissociative contribution of the bilateral anterior PFC.