The Neurochip BCI: Towards a neural prosthesis for upper limb function
The Neurochip BCI: Towards a neural prosthesis for upper limb function
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DOI：
10.1109/tnsre.2006.875547
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发表时间：
2006-06-01
影响因子：
4.9
通讯作者：
Fetz, Eberhard E.
中科院分区：
文献类型：
--
作者：
Jackson, Andrew;Moritz, Chet T.;Fetz, Eberhard E.
Neurochip BCI 是植入计算机芯片与神经系统中记录和刺激电极之间的自主操作接口。通过将一个大脑区域记录的神经活动转换为传递到另一个部位的电刺激，神经芯片脑机接口可以构成简单、直接的神经假体的基础。在对正常、不受约束的猴子进行的测试中，神经芯片连续数周记录初级运动皮层中单个神经元的活动。皮质活动与自由行为期间同时记录的手臂肌肉肌电图（EMG）活动相关。在对麻醉猴子进行的单独实验中，我们发现颈脊髓的微刺激会引起手臂和手的运动，通常涉及多个肌肉的协同作用。这些观察结果表明，由皮质神经元控制的脊髓微刺激可以帮助补偿受损的皮质脊髓投射。
The Neurochip BCI is an autonomously operating interface between an implanted computer chip and recording and stimulating electrodes in the nervous system. By converting neural activity recorded in one brain area into electrical stimuli delivered to another site, the Neurochip BCI could form the basis for a simple, direct neural prosthetic. In tests with normal, unrestrained monkeys, the Neurochip continuously recorded activity of single neurons in primary motor cortex for several weeks at a time. Cortical activity was correlated with simultaneously-recorded electromyogram (EMG) activity from arm muscles during free behavior. In separate experiments with anesthetized monkeys, we found that microstimulation of the cervical spinal cord evoked movements of the arm and hand, often involving multiple muscles synergies. These observations suggest that spinal microstimulation controlled by cortical neurons could help compensate for damaged corticospinal projections.