Prolonged incubation period of AIDS in intravenous drug abusers: epidemiological evidence in prison inmates.
Prolonged incubation period of AIDS in intravenous drug abusers: epidemiological evidence in prison inmates.
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静脉吸毒者艾滋病潜伏期延长：监狱囚犯的流行病学证据。
DOI：
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发表时间：
1984
影响因子：
6.4
通讯作者：
D. Morse
中科院分区：
文献类型：
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作者：
J. Hanrahan;G. Wormser;A. Reilly;B. Maguire;G. Gavis;D. Morse
研究对象是14名在纽约州立监狱服刑期间患上获得性免疫缺陷综合症（AIDS）的异性恋囚犯。这14人在入狱前都曾在纽约市经常静脉注射非法药物。当所有这些囚犯都健康的时候，进入州立监狱系统时的白细胞计数与作为对照的静脉注射毒品囚犯相比下降了三分之一（平均白细胞计数分别为4，430 vs. 6，320 cells/mm 3; P <0.005）; 14名患艾滋病的囚犯中有12人（86%）的细胞计数低于5,000个/mm 3，而42名对照者中只有6人（14%）低于5,000个/mm 3（P <0.00001）。14名囚犯在监禁后平均22.6 +/- 9.6个月出现艾滋病症状。我们的结论是，症状前艾滋病感染中经常发现白细胞减少症，并且静脉药物滥用者艾滋病的最低平均潜伏期相当长。
Fourteen heterosexual inmates who developed acquired immunodeficiency syndrome (AIDS) while incarcerated in New York state prisons were studied. All 14 had regularly used illicit drugs intravenously in New York City prior to imprisonment. Leukocyte counts on admission to the state prison system--when all of these inmates were well--were depressed by one-third when compared with those in matched intravenous drug-using inmates used as controls (mean leukocyte counts, 4,430 vs. 6,320 cells/mm3, respectively; P less than .005); twelve (86%) of the 14 inmates who developed AIDS had counts of less than 5,000 cells/mm3, compared with only six (14%) of the 42 controls (P less than .00001). The 14 inmates developed AIDS symptoms a mean of 22.6 +/- 9.6 months after imprisonment. We conclude that leukopenia is frequently to be found in presymptomatic AIDS infection and that the minimum mean incubation period of AIDS in intravenous-drug abusers is quite prolonged.