Robust filtering circuit design for stochastic gene networks under intrinsic and extrinsic molecular noises
Robust filtering circuit design for stochastic gene networks under intrinsic and extrinsic molecular noises
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DOI：
10.1016/j.mbs.2007.11.002
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发表时间：
2008-02-01
影响因子：
4.3
通讯作者：
Wu, Wei-Sheng
中科院分区：
文献类型：
--
作者：
Chen, Bor-Sen;Wu, Wei-Sheng
如何设计一个鲁棒的基因网络，以容忍更多的内在动力学参数的变化和衰减更多的外在环境噪声，以达到所需的过滤水平将是系统生物学和合成生物学的一个重要课题。目前还没有很好的系统设计方法来实现稳健的基因网络设计。在这项研究中，一个基因网络遭受的内在动力学参数波动和外在的环境噪声建模为一个朗之万方程与状态依赖的随机噪声。基于非线性随机滤波理论，提出了一种系统化的基因电路设计方法，使基因网络具有更强的鲁棒性，既能容忍更多的本征噪声，又能将非本征噪声衰减到预定的滤波水平。鲁棒基因网络设计原则不仅为鲁棒基因网络的设计提供了一个全面的理论框架，而且从系统的角度对基因网络的分子噪声滤除提供了有价值的见解。(c)2007年爱思唯尔公司All rights reserved.
How to design a robust gene network to tolerate more intrinsic kinetic parameter variations and to attenuate more extrinsic environmental noises to achieve a desired filtering level will be an important topic for systems biology and synthetic biology. At present, there is no good systematic design method to achieve robust gene network design. In this study, a gene network suffering from intrinsic kinetic parameter fluctuations and extrinsic environmental noises is modeled as a Langevin equation with state-dependent stochastic noises. Based on the nonlinear stochastic filtering theory, a systematic gene circuit design method is proposed to make gene networks improve their robustness to tolerate more intrinsic noises and to attenuate extrinsic noises to a prescribed filtering level. The robust gene network design principles have not only yielded a comprehensive design theory of robust gene networks, but also gained valuable insights into the molecular noise filtering of gene networks from the systematic perspective. (c) 2007 Elsevier Inc. All rights reserved.