THE LIVER ELIMINATES T-CELLS UNDERGOING ANTIGEN-TRIGGERED APOPTOSIS IN-VIVO
THE LIVER ELIMINATES T-CELLS UNDERGOING ANTIGEN-TRIGGERED APOPTOSIS IN-VIVO
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DOI：
10.1016/s1074-7613(94)80016-2
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发表时间：
1994-12-01
期刊：
影响因子：
32.4
通讯作者：
CRISPE, IN
中科院分区：
文献类型：
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作者：
HUANG, L;SOLDEVILA, G;CRISPE, IN
成熟外周T细胞的缺失可能是由细菌肠毒素、内源性前病毒编码的超抗原和肽抗原的TCR连接引起的。但被删除的T细胞的最终命运尚不清楚。使用一个行的T细胞受体转基因小鼠注射抗原肽，我们已经证明，外周删除伴随着诱导流产T细胞活化，然后由转基因阳性T细胞的消失。当这些T细胞从淋巴结和脾脏中消失时，它们在肝脏中积累，在那里它们经历凋亡。这可能是体内程序化进行凋亡的T细胞的一般清除途径，并且它可以进一步解释在T细胞凋亡机制中具有遗传缺陷的小鼠中肝内T细胞池的扩增，例如for突变体。
Deletion of mature peripheral T cells may result from TCR ligation by bacterial enterotoxins, endogenous provirus-encoded superantigens, and peptide antigens. But the ultimate fate of deleted T cells is not clear. Using a line of T cell receptor transgenic mice injected with antigenic peptide, we have documented that peripheral deletion is accompanied by the induction of abortive T cell activation followed by the disappearance of transgene-positive T cells. As these T cells disappear from the lymph nodes and spleen, they accumulate in the liver, where they undergo apoptosis. This is likely to be a general clearance pathway for T cells that are programmed to undergo apoptosis in vivo, and it may further explain the expansion of the intrahepatic T cell pool in mice with genetic defects in the T cell apoptosis mechanism, such as the for mutant.