Tuberculosis elimination in the Netherlands
Tuberculosis elimination in the Netherlands
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DOI：
10.3201/eid1104.041103
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发表时间：
2005-04-01
影响因子：
11.8
通讯作者：
van Soolingen, D
中科院分区：
文献类型：
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作者：
Borgdorff, MW;van der Werf, MJ;van Soolingen, D
这项研究通过使用DNA指纹技术评估了荷兰在消除结核病方面的进展。如果在过去2年内未在任何其他患者中观察到IS 6110限制性片段长度多态性模式，则结核分枝杆菌菌株被定义为新菌株。其他病例被定义为聚集性，并归因于最近的传播。在1995-2002年期间，非荷兰居民中新菌株结核病的发病率保持稳定，而荷兰居民中的发病率则有所下降。然而，荷兰人的下降仅限于65岁以上的人。此外，每种新菌株的继发病例平均数并没有随着时间的推移而发生显著变化。我们的结论是，荷兰过去结核病的下降。1999 - 2000年期间，艾滋病毒/艾滋病感染率下降主要是队列效应的结果：感染率高的年龄较大的出生队列被感染率较低的出生队列所取代。在目前的流行病学条件和控制努力下，结核病可能无法消除。
This study assessed progress towards tuberculosis (TB) elimination in the Netherlands by using DNA fingerprinting. Mycobacterium tuberculosis strains were defined as new if the IS6110 restriction fragment length polymorphism pattern had not been observed in any other patient during the previous 2 years. Other cases were defined as clustered and attributed to recent transmission. In the period 1995-2002, the incidence of TB with new strains was stable among non-Dutch residents and declined among the Dutch. However, the decline among the Dutch was restricted to those > 65 years of age. Moreover, the average number of secondary cases per new strain did not change significantly over time. We conclude that the decline of TB in the Netherlands over the past. decade was mainly the result of a cohort effect: older birth cohorts with high infection prevalence were replaced by those with lower infection prevalence. Under current epidemiologic conditions and control efforts, TB may not be eliminated.