Lower orbital frontal white matter integrity in adolescents with bipolar I disorder.
Lower orbital frontal white matter integrity in adolescents with bipolar I disorder.
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DOI：
10.1097/chi.0b013e3181900421
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发表时间：
2009-01
影响因子：
13.3
通讯作者：
Szeszko P
中科院分区：
文献类型：
--
作者：
Kafantaris V;Kingsley P;Ardekani B;Saito E;Lencz T;Lim K;Szeszko P
通过弥散张量成像 (DTI) 评估，检查患有 I 型双相情感障碍的青少年与对照志愿者的白质微观结构。 26 名（12 名男性和 14 名女性受试者）患有 I 型双相情感障碍的青少年（平均年龄为 16.0 岁）和 26 名（14 名男性和 12 名女性受试者）对照志愿者（平均年龄为 15.3 岁）完成了结构和 DTI 检查。在受试者间配准到 Talairach 空间后，使用体素分析对大脑白质中的分数各向异性 (FA) 和表观扩散系数 (ADC) 图进行比较。对 11 名具有可用神经心理学测量的患者进行了探索性分析，以评估其结构-功能相关性。与对照志愿者相比，患者的白质区域表现出异常，预计各组之间存在先验差异，包括右眼眶额叶的 FA 较低，左右膝下区域的 ADC 较高（p < .005，未校正；簇大小 ≥ 100）。与对照志愿者相比，患者没有出现较高 FA 或较低 ADC 的区域。各组之间差异显着的各区域 FA 较低与双相情感障碍患者视觉运动速度较慢显着相关。患有双相情感障碍的青少年涉及眶额叶和膝下白质的异常与神经生物学模型一致，该模型表明情感系统的失调和该疾病病理生理学中的冲动。初步研究结果表明，儿科双相情感障碍的白质异常具有功能相关性，可能有助于构建该疾病的神经生物学模型。
To examine white matter microstructure, as assessed via diffusion tensor imaging (DTI), in adolescents with bipolar I disorder compared with control volunteers. Twenty-six (12 male and 14 female subjects) adolescents (mean age, 16.0 years) with bipolar I disorder and 26 (14 male and 12 female subjects) control volunteers (mean age, 15.3 years) completed structural and DTI examinations. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) maps were compared between groups in the brain white matter using a voxelwise analysis after intersubject registration to Talairach space. Exploratory analyses were performed to assess structure–function correlations in a subgroup of 11 patients with available neuropsychological measures. Compared with the control volunteers, the patients demonstrated abnormalities in white matter regions predicted to differ a priori between groups, including lower FA in the right orbital frontal lobe and higher ADC in the right and left subgenual region (p < .005, uncorrected; cluster size ≥ 100). There were no areas of higher FA or lower ADC in patients compared with control volunteers. Lower FA across regions that differed significantly between groups correlated significantly with slower visuomotor speed among patients with bipolar disorder. Abnormalities involving the orbital frontal and subgenual white matter in adolescents with bipolar disorder are consistent with neurobiological models that implicate dysregulation of affective systems and impulsivity in the pathophysiology of the disorder. Preliminary findings suggest that white matter abnormalities in pediatric bipolar disorder have functional correlates and may be useful in constructing neurobiological models of the disorder.